Detailed information of TA system TA110913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 292028..292648
• Replicon: chromosome
• Accession: NZ_CP032002
• Organism: Acinetobacter haemolyticus strain 11616

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: Ahae11616_RS01360
• Protein ID: WP_008941148.1
• Coordinates: 292238..292648 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: Ahae11616_RS01355
• Protein ID: WP_008941147.1
• Coordinates: 292028..292237 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ahae11616_RS01330	287073..288494	+	1422	WP_005087020.1	FAD-dependent oxidoreductase	-
Ahae11616_RS01335	288665..289555	+	891	Protein_253	metal-dependent hydrolase	-
Ahae11616_RS01340	289729..290319	+	591	WP_008941144.1	LemA family protein	-
Ahae11616_RS01345	290343..291401	+	1059	WP_008941145.1	TPM domain-containing protein	-
Ahae11616_RS01350	291395..291955	+	561	WP_008941146.1	TPM domain-containing protein	-
Ahae11616_RS01355	292028..292237	+	210	WP_008941147.1	antitoxin	Antitoxin
Ahae11616_RS01360	292238..292648	+	411	WP_008941148.1	tRNA(fMet)-specific endonuclease VapC	Toxin
Ahae11616_RS01365	292798..293988	+	1191	WP_008941149.1	Fic family protein	-
Ahae11616_RS01370	294345..294839	+	495	WP_151800466.1	pilin	-
Ahae11616_RS01375	294916..295656	+	741	WP_151800465.1	type4 fimbrial accessory protein	-
Ahae11616_RS01380	295810..296238	+	429	WP_160124155.1	pilin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	285685..407233	121548

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15384.81 Da
• Isoelectric Point: 8.8849

>T110913 WP_008941148.1 NZ_CP032002:292238-292648 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTIKQRPLAVKERFNAVSTQLCISSITVAELIFGAENSQMPEKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRKGQPIGENDLHIAAHARSRGLILVTNNTREFERVPALQIENWLKESG

Nucleotide

• Length: 411 bp

>T110913 NZ_CP032002:292238-292648 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTTGATACCAATATTGTGATTTATACAATAAAACAAAGACCACTGGCGGTTAAAGAAAGGTTTAA
TGCTGTTTCAACACAACTTTGTATCAGTAGTATCACTGTTGCGGAATTAATTTTTGGGGCGGAAAATAGCCAAATGCCCG
AGAAGAATTTAAAAGTTGTAGAGGATTTTTTATCACGATTGCAAATTTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAAAAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACCAATAATACAAGAGAGTTTGAGCGTGTGCCTGCACTACAGATAGAAAACTGGTTGAAAG
AAAGCGGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT110913 WP_008941147.1 NZ_CP032002:292028-292237 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT110913 NZ_CP032002:292028-292237 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTAGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGTGGCGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8