Detailed information of TA system TA110912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3222455..3223075
• Replicon: chromosome
• Accession: NZ_CP031998
• Organism: Acinetobacter haemolyticus strain INNSZ174

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AhaeINNSZ174_RS15495
• Protein ID: WP_008941148.1
• Coordinates: 3222455..3222865 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: AhaeINNSZ174_RS15500
• Protein ID: WP_008941147.1
• Coordinates: 3222866..3223075 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeINNSZ174_RS15475	3218865..3219293	-	429	WP_151800464.1	pilin	-
AhaeINNSZ174_RS15480	3219447..3220187	-	741	WP_151800465.1	type4 fimbrial accessory protein	-
AhaeINNSZ174_RS15485	3220264..3220758	-	495	WP_151800466.1	pilin	-
AhaeINNSZ174_RS15490	3221115..3222305	-	1191	WP_008941149.1	Fic family protein	-
AhaeINNSZ174_RS15495	3222455..3222865	-	411	WP_008941148.1	tRNA(fMet)-specific endonuclease VapC	Toxin
AhaeINNSZ174_RS15500	3222866..3223075	-	210	WP_008941147.1	antitoxin	Antitoxin
AhaeINNSZ174_RS15505	3223148..3223708	-	561	WP_008941146.1	TPM domain-containing protein	-
AhaeINNSZ174_RS15510	3223702..3224760	-	1059	WP_008941145.1	TPM domain-containing protein	-
AhaeINNSZ174_RS15515	3224784..3225374	-	591	WP_008941144.1	LemA family protein	-
AhaeINNSZ174_RS15520	3225548..3226438	-	891	Protein_3021	metal-dependent hydrolase	-
AhaeINNSZ174_RS15525	3226609..3228030	-	1422	WP_005087020.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3071400..3239597	168197

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15384.81 Da
• Isoelectric Point: 8.8849

>T110912 WP_008941148.1 NZ_CP031998:c3222865-3222455 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTIKQRPLAVKERFNAVSTQLCISSITVAELIFGAENSQMPEKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRKGQPIGENDLHIAAHARSRGLILVTNNTREFERVPALQIENWLKESG

Nucleotide

• Length: 411 bp

>T110912 NZ_CP031998:c3222865-3222455 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTTGATACCAATATTGTGATTTATACAATAAAACAAAGACCACTGGCGGTTAAAGAAAGGTTTAA
TGCTGTTTCAACACAACTTTGTATCAGTAGTATCACTGTTGCGGAATTAATTTTTGGGGCGGAAAATAGCCAAATGCCCG
AGAAGAATTTAAAAGTTGTAGAGGATTTTTTATCACGATTGCAAATTTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAAAAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACCAATAATACAAGAGAGTTTGAGCGTGTGCCTGCACTACAGATAGAAAACTGGTTGAAAG
AAAGCGGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT110912 WP_008941147.1 NZ_CP031998:c3223075-3222866 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT110912 NZ_CP031998:c3223075-3222866 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTAGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGTGGCGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8