Detailed information of TA system TA110910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2285242..2285752
• Replicon: chromosome
• Accession: NZ_CP031998
• Organism: Acinetobacter haemolyticus strain INNSZ174

Toxin (Protein)

• Gene name: relB
• Uniprot ID: N8PSJ1
• Locus tag: AhaeINNSZ174_RS10985
• Protein ID: WP_004671840.1
• Coordinates: 2285489..2285752 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AhaeINNSZ174_RS10980
• Protein ID: WP_125317037.1
• Coordinates: 2285242..2285505 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeINNSZ174_RS10955	2280798..2282381	-	1584	WP_005080957.1	IS66-like element ISAba25 family transposase	-
AhaeINNSZ174_RS10960	2282456..2282767	-	312	WP_158319084.1	IS66 family insertion sequence element accessory protein TnpB	-
AhaeINNSZ174_RS10965	2282788..2283171	-	384	WP_001055585.1	IS66 family insertion sequence hypothetical protein	-
AhaeINNSZ174_RS10970	2283425..2284465	+	1041	WP_160124242.1	hypothetical protein	-
AhaeINNSZ174_RS10975	2284559..2284825	+	267	WP_125317006.1	AlpA family phage regulatory protein	-
AhaeINNSZ174_RS10980	2285242..2285505	+	264	WP_125317037.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AhaeINNSZ174_RS10985	2285489..2285752	+	264	WP_004671840.1	Txe/YoeB family addiction module toxin	Toxin
AhaeINNSZ174_RS10990	2286288..2286671	+	384	WP_001055585.1	IS66 family insertion sequence hypothetical protein	-
AhaeINNSZ174_RS10995	2286692..2287003	+	312	WP_158319084.1	IS66 family insertion sequence element accessory protein TnpB	-
AhaeINNSZ174_RS11000	2287078..2288661	+	1584	WP_005080957.1	IS66-like element ISAba25 family transposase	-
AhaeINNSZ174_RS11005	2288694..2289674	+	981	Protein_2146	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2272320..2289674	17354
	-	inside	IScluster/Tn	-	-	2278485..2288661	10176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10358.93 Da
• Isoelectric Point: 9.0098

>T110910 WP_004671840.1 NZ_CP031998:2285489-2285752 [Acinetobacter haemolyticus]
MKRKTSFTPTAWEDYVYWQSQDKKTLKRINTLIKECLRTPFEGIGKPEPLLGDLAGFWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T110910 NZ_CP031998:2285489-2285752 [Acinetobacter haemolyticus]
ATGAAACGGAAGACTAGTTTTACTCCAACAGCTTGGGAAGATTATGTGTACTGGCAAAGCCAAGACAAAAAAACGCTTAA
GCGCATCAATACATTAATCAAAGAGTGTCTTCGTACTCCCTTTGAAGGTATTGGCAAGCCTGAACCATTACTCGGTGATT
TAGCAGGTTTTTGGAGCAGGCGAATAGATGAGAAAAATAGATTAGTCTATGAAGTAACTGATGTAGCAATCACAATAATT
TCTTGTCGTTATCACTATGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9882.05 Da
• Isoelectric Point: 4.3176

>AT110910 WP_125317037.1 NZ_CP031998:2285242-2285505 [Acinetobacter haemolyticus]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLYLMSSPSNATHLAQSIAELRASKTIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT110910 NZ_CP031998:2285242-2285505 [Acinetobacter haemolyticus]
ATGCAAATTTTCACTTATACCGATGCTCGCAATAATCTGAAAACGGTTTTAGACCGTGTTATTGATGATTCAGATGTTGC
AGTAATTACGAGGAAAGAAGGTCAACATGCCGTTGTAATGGGACAAGACTATTACAACAGTATAATGGAAACATTGTACC
TCATGTCTTCTCCAAGTAACGCAACACACTTAGCGCAGTCAATTGCAGAGTTACGAGCGTCTAAAACAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A3Q8XJ07