Detailed information of TA system TA110907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1840224..1841860
• Replicon: chromosome
• Accession: NZ_CP031998
• Organism: Acinetobacter haemolyticus strain INNSZ174

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A5P1UU42
• Locus tag: AhaeINNSZ174_RS08845
• Protein ID: WP_005090545.1
• Coordinates: 1840529..1841860 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: AhaeINNSZ174_RS08840
• Protein ID: WP_005090546.1
• Coordinates: 1840224..1840532 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeINNSZ174_RS08820	1836544..1837293	+	750	WP_005080786.1	iron-containing redox enzyme family protein	-
AhaeINNSZ174_RS08825	1837366..1838067	-	702	WP_160132500.1	NAD(P)H-dependent oxidoreductase	-
AhaeINNSZ174_RS08830	1838199..1839231	+	1033	Protein_1714	AraC family transcriptional regulator ligand-binding domain-containing protein	-
AhaeINNSZ174_RS08835	1839508..1840182	-	675	WP_005090547.1	DUF4145 domain-containing protein	-
AhaeINNSZ174_RS08840	1840224..1840532	-	309	WP_005090546.1	helix-turn-helix domain-containing protein	Antitoxin
AhaeINNSZ174_RS08845	1840529..1841860	-	1332	WP_005090545.1	HipA domain-containing protein	Toxin
AhaeINNSZ174_RS08850	1842098..1842796	+	699	WP_005090543.1	DUF1826 domain-containing protein	-
AhaeINNSZ174_RS08855	1842928..1843860	+	933	WP_020846310.1	IS5 family transposase	-
AhaeINNSZ174_RS08860	1843890..1845047	-	1158	WP_160132501.1	WG repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1842991..1843860	869

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-387)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 50765.55 Da
• Isoelectric Point: 4.8292

>T110907 WP_005090545.1 NZ_CP031998:c1841860-1840529 [Acinetobacter haemolyticus]
MQKLTIQALLDQNWLDIAELKLLEPKLGSASASELVYELEYAIQNLDKRDEHACSLSLPVQILINHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTYAEQDSILLEKGGIAPVGNLRIKEALPPINPDSTLHLRYFSQNDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWRNQCWQRHGLESVYSVLNKASGSHLNHFEVIDNLCDLLTVIDSNFDSTQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWEQITQKLAHLCDPNLSMKTLK
SLANNLVGLKQRLIDKGVPKQIMEMPALSFDYVEAKLERWELL

Nucleotide

• Length: 1332 bp

>T110907 NZ_CP031998:c1841860-1840529 [Acinetobacter haemolyticus]
ATGCAAAAATTAACAATACAGGCTTTACTCGACCAGAATTGGTTAGATATCGCTGAACTTAAACTATTAGAACCTAAGCT
GGGCTCAGCAAGCGCCAGTGAATTGGTCTACGAGTTGGAATACGCAATCCAAAATCTGGACAAGCGAGATGAACATGCCT
GTAGTCTCTCACTTCCTGTACAAATACTTATAAACCATGAATCTAGCTCATGGTTTGGTTTTTTGGATGATATTGTTCCT
TCAGGCGCAGCGCGCCGTTATTGGGTCAATTTTTTAGGCTTACAACGACTCACTTATGCTGAGCAAGATAGTATTTTATT
GGAAAAGGGTGGAATTGCGCCCGTAGGAAACTTGCGAATTAAAGAAGCTCTTCCGCCTATAAATCCTGACTCTACTTTGC
ATTTACGTTATTTTAGTCAAAATGATGTTGCTGATCGAAATGTTGATTTTCTTGAGTATGCACAGCAAATGGGCGCGATT
AGTGGTGGTGCAACAGGAGCGGGTGGTGAAGCGCCCAAGTTACTGATTCGCGCGACAAAAGATCAAAATATTTGGATTGA
CACCTATCAACAAAACTTTGATCAACCTGATCAACACTATTTAGTTAAATTTCCTCGAAATAATCGTAGTGAGATCGACT
GCAATATTCTCAGAGCGGAATACTATTACTATCAAGAACTAAAAGAATTAGGTTTCAATACCATTGAAACAACAGAAATG
AAGCTGATCGAAGGTGAAAAATATCCATCATTATGGTTGCCAAGATTTGATGTGGAATGGCGCAATCAATGTTGGCAACG
TCATGGTCTAGAATCTGTTTATTCAGTATTAAATAAGGCTTCAGGAAGTCATCTTAATCATTTTGAAGTAATAGACAACC
TATGTGATTTACTGACAGTGATTGATTCAAATTTTGATTCCACACAATTCGTTTGTGAATGGTTACAAAGAGACTTGCTC
AATATTATTTTTGGCAATTCTGATAATCACGGGCGAAATACCTCATTTCTAAAAAAATCTGGAAAAATTTCGCTTGCTCC
AATTTATGATTTTGCACCAATGAAAGCTGATCCAGAAGTCGTGACAAGATCAACGACATGGGGAAGTCCTTATGAAGAAG
GAGGAGAGTATCGTTGGGAGCAAATTACCCAGAAACTTGCACATTTATGCGATCCAAATTTGTCTATGAAGACATTAAAA
TCATTAGCAAACAATCTTGTTGGGCTAAAACAACGATTAATTGATAAAGGTGTCCCAAAACAGATTATGGAGATGCCAGC
ACTTTCATTCGATTATGTTGAAGCTAAATTAGAAAGATGGGAACTATTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11716.80 Da
• Isoelectric Point: 10.1562

>AT110907 WP_005090546.1 NZ_CP031998:c1840532-1840224 [Acinetobacter haemolyticus]
MNIKNQPQDRQKVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKLSE

Nucleotide

• Length: 309 bp

>AT110907 NZ_CP031998:c1840532-1840224 [Acinetobacter haemolyticus]
ATGAATATAAAAAATCAGCCTCAAGATCGCCAGAAAGTTCTTATTGATCTATATATGCAGTACTTATTGAATGAAATTAC
CTTAGGGCAATTATTGGCGTATTTGCGAAAAAATATACTTGGCATGTCTCAGGAACAATACGCAAATTTGGTCGGTGTCA
GTCGCAGAACATTAACGGACATAGAACAAGACAAAGGAAAACTCACGCAATCTGTTTTAGATAAAGTATTTAAACCACTG
GGATTGAAAGCAGGACTTGTACCGACTCATGAGCATATTGTGAGGAAGATTATTAAATTATCAGAGTGA

Structures

Toxin

• AlphaFold DB: A0A5P1UU42