Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 116180..116693 Replicon chromosome
Accession NZ_CP031998
Organism Acinetobacter haemolyticus strain INNSZ174

Toxin (Protein)


Gene name yoeB Uniprot ID A0A558EQR2
Locus tag AhaeINNSZ174_RS00535 Protein ID WP_043975117.1
Coordinates 116180..116443 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S7WSW9
Locus tag AhaeINNSZ174_RS00540 Protein ID WP_000557943.1
Coordinates 116430..116693 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeINNSZ174_RS00505 111391..112164 + 774 WP_118902192.1 enoyl-CoA hydratase -
AhaeINNSZ174_RS00510 112178..113203 + 1026 WP_017395165.1 enoyl-CoA hydratase/isomerase family protein -
AhaeINNSZ174_RS00515 113322..114674 + 1353 WP_118902195.1 MHS family MFS transporter -
AhaeINNSZ174_RS00520 114800..115264 + 465 WP_008942447.1 GNAT family N-acetyltransferase -
AhaeINNSZ174_RS00525 115575..115907 + 333 Protein_98 transposase -
AhaeINNSZ174_RS00530 115953..116108 + 156 Protein_99 IS5/IS1182 family transposase -
AhaeINNSZ174_RS00535 116180..116443 - 264 WP_043975117.1 Txe/YoeB family addiction module toxin Toxin
AhaeINNSZ174_RS00540 116430..116693 - 264 WP_000557943.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AhaeINNSZ174_RS00545 117109..120456 + 3348 WP_125316849.1 DEAD/DEAH box helicase -
AhaeINNSZ174_RS00550 120474..121157 - 684 Protein_103 HipA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10680.10 Da        Isoelectric Point: 7.8508

>T110906 WP_043975117.1 NZ_CP031998:c116443-116180 [Acinetobacter haemolyticus]
MTSRNVEWTENAWDEYIYWQTQDKKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
VQCWFHY

Download         Length: 264 bp

>T110906 NZ_CP031998:c116443-116180 [Acinetobacter haemolyticus]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGAAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
GTTCAATGTTGGTTCCATTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9841.04 Da        Isoelectric Point: 5.5940

>AT110906 WP_000557943.1 NZ_CP031998:c116693-116430 [Acinetobacter haemolyticus]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Download         Length: 264 bp

>AT110906 NZ_CP031998:c116693-116430 [Acinetobacter haemolyticus]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGACAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A558EQR2

Antitoxin

Source ID Structure
AlphaFold DB S7WSW9

References