Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2401..2981 Replicon plasmid pAhaem2126che
Accession NZ_CP031993
Organism Acinetobacter haemolyticus strain 2126ch

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H8SLW2
Locus tag Ahae2126ch_RS17470 Protein ID WP_044425274.1
Coordinates 2401..2649 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7H8SKS1
Locus tag Ahae2126ch_RS17475 Protein ID WP_035270373.1
Coordinates 2646..2981 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ahae2126ch_RS17455 1..936 + 936 WP_005086339.1 replication initiation protein RepM -
Ahae2126ch_RS17460 1005..1550 + 546 WP_017394741.1 plasmid replication DNA-binding protein -
Ahae2126ch_RS17465 1768..2295 + 528 WP_151800612.1 plasmid pRiA4b ORF-3 family protein -
Ahae2126ch_RS17470 2401..2649 + 249 WP_044425274.1 type II toxin-antitoxin system HicA family toxin Toxin
Ahae2126ch_RS17475 2646..2981 + 336 WP_035270373.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Ahae2126ch_RS17480 3095..3943 - 849 WP_005331680.1 LysR family transcriptional regulator -
Ahae2126ch_RS17485 4044..5279 + 1236 WP_005331677.1 alpha/beta fold hydrolase -
Ahae2126ch_RS17490 5493..5804 + 312 WP_005091751.1 BrnT family toxin -
Ahae2126ch_RS17495 5767..6081 + 315 WP_005091750.1 BrnA antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..21807 21807


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9451.04 Da        Isoelectric Point: 10.3195

>T110905 WP_044425274.1 NZ_CP031993:2401-2649 [Acinetobacter haemolyticus]
MGKTEKLLEKFGNSKNTFPYKDLVVLLNQLGYEKFEMAGSRVRFFNTKTEHMILLHRPHPENEIKGGALKSVKQALKQEG
FL

Download         Length: 249 bp

>T110905 NZ_CP031993:2401-2649 [Acinetobacter haemolyticus]
ATGGGTAAAACGGAAAAGTTACTGGAAAAATTTGGAAATTCAAAAAATACATTTCCGTATAAAGATTTAGTCGTTTTACT
GAATCAGCTCGGCTATGAAAAATTTGAAATGGCAGGCTCTCGTGTCCGTTTTTTTAATACGAAAACTGAACACATGATTT
TACTGCACAGGCCACACCCTGAAAATGAAATCAAAGGTGGGGCTTTGAAATCTGTAAAACAGGCACTCAAGCAGGAGGGA
TTTTTATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12411.14 Da        Isoelectric Point: 4.7146

>AT110905 WP_035270373.1 NZ_CP031993:2646-2981 [Acinetobacter haemolyticus]
MSYLKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKTLEQAFQESVDGYLESCAELGKKPDQPFKGTFNVRISPE
LHRKAVLASSDNSLNAFVSDAIQEKLMRLGA

Download         Length: 336 bp

>AT110905 NZ_CP031993:2646-2981 [Acinetobacter haemolyticus]
ATGAGCTATTTAAAATACAAAGGTTATCTAGGTACAATTGAACCTGATCTTGAAACAGGTGAGTTATTTGGAAAGCTTGC
ATTTATCCGTGATCTCATCACTTATGAAGCAGAAACATTAAAAACTCTTGAACAAGCTTTTCAGGAATCTGTCGATGGAT
ATTTAGAGTCTTGTGCTGAATTAGGTAAAAAACCCGATCAGCCATTCAAAGGTACATTTAATGTCCGTATTAGTCCTGAG
TTACACCGTAAAGCTGTTTTAGCATCAAGTGATAATTCTCTTAATGCTTTTGTAAGCGATGCGATTCAAGAGAAATTAAT
GCGTTTAGGTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8SLW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7H8SKS1

References