Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1659033..1660165 Replicon chromosome
Accession NZ_CP031991
Organism Acinetobacter haemolyticus strain 2126ch

Toxin (Protein)


Gene name - Uniprot ID A0A2K8PX24
Locus tag Ahae2126ch_RS08060 Protein ID WP_017396077.1
Coordinates 1659033..1659797 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag Ahae2126ch_RS08065 Protein ID WP_004639219.1
Coordinates 1659794..1660165 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ahae2126ch_RS08035 1654941..1655798 + 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -
Ahae2126ch_RS08040 1655890..1657179 + 1290 WP_004639224.1 phosphopyruvate hydratase -
Ahae2126ch_RS08045 1657309..1657674 + 366 WP_004639223.1 cell division protein FtsB -
Ahae2126ch_RS08050 1657664..1658371 + 708 WP_115736412.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
Ahae2126ch_RS08055 1658498..1658974 + 477 WP_005090442.1 hypothetical protein -
Ahae2126ch_RS08060 1659033..1659797 - 765 WP_017396077.1 RES family NAD+ phosphorylase Toxin
Ahae2126ch_RS08065 1659794..1660165 - 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
Ahae2126ch_RS08070 1660403..1661335 - 933 WP_020846310.1 IS5 family transposase -
Ahae2126ch_RS08075 1661429..1661842 + 414 WP_005080585.1 YeeE/YedE family protein -
Ahae2126ch_RS08085 1663084..1663446 + 363 WP_160140355.1 YeeE/YedE family protein -
Ahae2126ch_RS08090 1663461..1664333 + 873 WP_005080588.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29082.00 Da        Isoelectric Point: 5.8003

>T110902 WP_017396077.1 NZ_CP031991:c1659797-1659033 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWHSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGIEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

>T110902 NZ_CP031991:c1659797-1659033 [Acinetobacter haemolyticus]
ATGACTGCCATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACTAGGCAGTTGGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGATCACGTTTCGGTCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGCACTCAATGGATGGTGCACCAAAGAAAAAAACGATACGCACTGAGCATA
CTCTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATCTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGCACAGCAATGCGGAATGAAGGAATTGAGATCTTTGAATATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAGCCAAAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT110902 WP_004639219.1 NZ_CP031991:c1660165-1659794 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp

>AT110902 NZ_CP031991:c1660165-1659794 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTACTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTCGAGGTAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PX24

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References