Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 490849..491488 Replicon chromosome
Accession NZ_CP031991
Organism Acinetobacter haemolyticus strain 2126ch

Toxin (Protein)


Gene name cptA Uniprot ID C0VNL5
Locus tag Ahae2126ch_RS02355 Protein ID WP_005088316.1
Coordinates 491093..491488 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C0VNL4
Locus tag Ahae2126ch_RS02350 Protein ID WP_005088318.1
Coordinates 490849..491106 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ahae2126ch_RS02330 486452..486949 + 498 WP_004641030.1 GNAT family N-acetyltransferase -
Ahae2126ch_RS02335 487328..488818 + 1491 WP_005086827.1 NAD(P)/FAD-dependent oxidoreductase -
Ahae2126ch_RS02340 488941..489438 + 498 WP_005088321.1 DUF2059 domain-containing protein -
Ahae2126ch_RS02345 489490..490662 - 1173 WP_005086825.1 acyl-CoA dehydrogenase family protein -
Ahae2126ch_RS02350 490849..491106 + 258 WP_005088318.1 succinate dehydrogenase assembly factor 2 Antitoxin
Ahae2126ch_RS02355 491093..491488 + 396 WP_005088316.1 hypothetical protein Toxin
Ahae2126ch_RS02360 491699..491905 + 207 WP_026056364.1 hypothetical protein -
Ahae2126ch_RS02365 492265..493308 + 1044 WP_004641019.1 hypothetical protein -
Ahae2126ch_RS02370 493436..494017 + 582 WP_004641018.1 rhombosortase -
Ahae2126ch_RS02375 494195..496405 + 2211 WP_004641016.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 485608..486312 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 16153.44 Da        Isoelectric Point: 9.1954

>T110901 WP_005088316.1 NZ_CP031991:491093-491488 [Acinetobacter haemolyticus]
MSTADRVFVLKRSRFAFAFQLFIFIVLISLLYYLLPWFLWLVSFPLMLIAWVLLLKQPQLKHFEYLDDQLCSLCFSDEMQ
RIEQRKIRKMIDHQCYIVIYFYDSQCRPCVIWWDQLSILQWKKLRTWVKLA

Download         Length: 396 bp

>T110901 NZ_CP031991:491093-491488 [Acinetobacter haemolyticus]
ATGTCCACGGCTGATCGTGTTTTTGTGTTGAAACGCAGTCGTTTTGCATTTGCGTTTCAACTTTTTATTTTTATCGTACT
GATCAGTTTATTGTATTACTTACTTCCTTGGTTTTTATGGCTTGTTAGCTTTCCTTTGATGCTAATTGCTTGGGTATTAT
TACTCAAACAACCTCAGCTTAAACACTTTGAATATTTAGATGATCAGCTTTGCTCCTTGTGTTTTAGTGATGAGATGCAG
AGGATCGAGCAAAGGAAAATTCGAAAAATGATCGATCATCAATGTTATATCGTCATCTATTTTTATGACTCTCAATGTCG
ACCTTGTGTGATTTGGTGGGATCAATTGTCGATTTTACAGTGGAAAAAGCTCAGAACATGGGTCAAACTTGCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10012.44 Da        Isoelectric Point: 4.4558

>AT110901 WP_005088318.1 NZ_CP031991:490849-491106 [Acinetobacter haemolyticus]
MSEELTLEERKVIYRARRGLKEIDVYFDPYVKNCYLTADATEKALFAELVDQEDPDLLDWFMEVGEPPRPELKAFISKLK
QYVHG

Download         Length: 258 bp

>AT110901 NZ_CP031991:490849-491106 [Acinetobacter haemolyticus]
ATGTCTGAAGAATTGACACTAGAAGAACGTAAAGTGATTTATCGTGCGCGTCGTGGTTTGAAAGAAATCGATGTGTATTT
TGATCCTTATGTCAAAAATTGTTATCTCACAGCAGATGCGACTGAGAAAGCATTGTTTGCAGAGTTGGTAGATCAAGAAG
ATCCTGATTTACTGGATTGGTTCATGGAGGTGGGTGAACCTCCTCGTCCAGAGTTAAAAGCGTTTATTTCAAAATTAAAA
CAGTATGTCCACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6KJV0

Antitoxin

Source ID Structure
AlphaFold DB A0A372MSY6

References