Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1748468..1749600 Replicon chromosome
Accession NZ_CP031988
Organism Acinetobacter haemolyticus strain 5227

Toxin (Protein)


Gene name - Uniprot ID C0VPL6
Locus tag Ahae5227_RS08555 Protein ID WP_004639220.1
Coordinates 1748468..1749232 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag Ahae5227_RS08560 Protein ID WP_004639219.1
Coordinates 1749229..1749600 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ahae5227_RS08530 1744376..1745233 + 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -
Ahae5227_RS08535 1745325..1746614 + 1290 WP_004639224.1 phosphopyruvate hydratase -
Ahae5227_RS08540 1746744..1747109 + 366 WP_004639223.1 cell division protein FtsB -
Ahae5227_RS08545 1747099..1747806 + 708 WP_004639222.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
Ahae5227_RS08550 1747933..1748409 + 477 WP_005090442.1 hypothetical protein -
Ahae5227_RS08555 1748468..1749232 - 765 WP_004639220.1 RES family NAD+ phosphorylase Toxin
Ahae5227_RS08560 1749229..1749600 - 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
Ahae5227_RS08565 1749816..1750229 + 414 WP_005080585.1 YeeE/YedE family protein -
Ahae5227_RS08570 1750231..1750644 + 414 WP_005090445.1 YeeE/YedE family protein -
Ahae5227_RS08575 1750659..1751564 + 906 WP_160123881.1 MBL fold metallo-hydrolase -
Ahae5227_RS08580 1751598..1752688 + 1091 WP_100222603.1 IS4-like element ISAba33 family transposase -
Ahae5227_RS08585 1752889..1753587 + 699 WP_005080590.1 phosphoglycerate mutase family protein -
Ahae5227_RS08590 1753727..1753987 + 261 WP_005080592.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29094.01 Da        Isoelectric Point: 5.5775

>T110898 WP_004639220.1 NZ_CP031988:c1749232-1748468 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWYSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGVEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

>T110898 NZ_CP031988:c1749232-1748468 [Acinetobacter haemolyticus]
ATGACCGCCATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACTAGGCAGTTGGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGGTCACGTTTCGGTCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGTACTCAATGGATGGTGCACCAAAGAAAAAAACGATACGCACTGAGCATA
CTTTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATCTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGTACAGCAATGCGGAATGAAGGAGTTGAGATCTTTGAGTATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAGCCAGAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT110898 WP_004639219.1 NZ_CP031988:c1749600-1749229 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp

>AT110898 NZ_CP031988:c1749600-1749229 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTACTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTAGAGGTAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A372MQ11

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References