Detailed information of TA system TA110895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 334760..335380
• Replicon: chromosome
• Accession: NZ_CP031988
• Organism: Acinetobacter haemolyticus strain 5227

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: Ahae5227_RS01535
• Protein ID: WP_008941148.1
• Coordinates: 334970..335380 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: Ahae5227_RS01530
• Protein ID: WP_008941147.1
• Coordinates: 334760..334969 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ahae5227_RS01505	329805..331226	+	1422	WP_005087020.1	FAD-dependent oxidoreductase	-
Ahae5227_RS01510	331397..332287	+	891	Protein_287	metal-dependent hydrolase	-
Ahae5227_RS01515	332461..333051	+	591	WP_008941144.1	LemA family protein	-
Ahae5227_RS01520	333075..334133	+	1059	WP_008941145.1	TPM domain-containing protein	-
Ahae5227_RS01525	334127..334687	+	561	WP_008941146.1	TPM domain-containing protein	-
Ahae5227_RS01530	334760..334969	+	210	WP_008941147.1	antitoxin	Antitoxin
Ahae5227_RS01535	334970..335380	+	411	WP_008941148.1	tRNA(fMet)-specific endonuclease VapC	Toxin
Ahae5227_RS01540	335530..336720	+	1191	WP_008941149.1	Fic family protein	-
Ahae5227_RS01545	337077..337571	+	495	WP_151800466.1	pilin	-
Ahae5227_RS01550	337648..338388	+	741	WP_151800465.1	type4 fimbrial accessory protein	-
Ahae5227_RS17735	338542..338652	+	111	Protein_296	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
Ahae5227_RS01560	338789..339954	+	1166	WP_085940844.1	IS3-like element ISAba22 family transposase	-
Ahae5227_RS01565	340026..340247	+	222	WP_008941151.1	pilin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15384.81 Da
• Isoelectric Point: 8.8849

>T110895 WP_008941148.1 NZ_CP031988:334970-335380 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTIKQRPLAVKERFNAVSTQLCISSITVAELIFGAENSQMPEKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRKGQPIGENDLHIAAHARSRGLILVTNNTREFERVPALQIENWLKESG

Nucleotide

• Length: 411 bp

>T110895 NZ_CP031988:334970-335380 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTTGATACCAATATTGTGATTTATACAATAAAACAAAGACCACTGGCGGTTAAAGAAAGGTTTAA
TGCTGTTTCAACACAACTTTGTATCAGTAGTATCACTGTTGCGGAATTAATTTTTGGGGCGGAAAATAGCCAAATGCCCG
AGAAGAATTTAAAAGTTGTAGAGGATTTTTTATCACGATTGCAAATTTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAAAAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACCAATAATACAAGAGAGTTTGAGCGTGTGCCTGCACTACAGATAGAAAACTGGTTGAAAG
AAAGCGGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT110895 WP_008941147.1 NZ_CP031988:334760-334969 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT110895 NZ_CP031988:334760-334969 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTAGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGTGGCGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8