Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parE-paaA/RelE(toxin)
Location 2150..2597 Replicon plasmid pAhaemAN3a
Accession NZ_CP031987
Organism Acinetobacter haemolyticus strain AN3

Toxin (Protein)


Gene name parE Uniprot ID N8RH88
Locus tag AhaeAN3_RS16015 Protein ID WP_004676351.1
Coordinates 2325..2597 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D0SRM7
Locus tag AhaeAN3_RS16010 Protein ID WP_005404020.1
Coordinates 2150..2338 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeAN3_RS16005 1034..2086 + 1053 WP_160127447.1 replication initiation protein RepM -
AhaeAN3_RS16010 2150..2338 + 189 WP_005404020.1 hypothetical protein Antitoxin
AhaeAN3_RS16015 2325..2597 + 273 WP_004676351.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AhaeAN3_RS16020 2588..2890 - 303 WP_160127448.1 mobilization protein -
AhaeAN3_RS16025 3011..3223 - 213 WP_160127449.1 hypothetical protein -
AhaeAN3_RS16030 3300..3533 - 234 WP_160127450.1 hypothetical protein -
AhaeAN3_RS16035 3536..4621 - 1086 WP_160127453.1 protein rep -
AhaeAN3_RS16040 4820..5107 - 288 WP_160127451.1 hypothetical protein -
AhaeAN3_RS16045 5644..5892 - 249 WP_160127452.1 hypothetical protein -
AhaeAN3_RS16050 6055..6852 + 798 Protein_9 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..7222 7222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10426.80 Da        Isoelectric Point: 5.4807

>T110894 WP_004676351.1 NZ_CP031987:2325-2597 [Acinetobacter haemolyticus]
MLIVKWQPTAVEDLEAIIDYIANHNTVAAYDLEDHILQSAEDLAEHPYKGRNGRRAGTRELLVHPNYWLVYEVSDLIRIT
NVIHTSRLYP

Download         Length: 273 bp

>T110894 NZ_CP031987:2325-2597 [Acinetobacter haemolyticus]
ATGCTAATCGTTAAGTGGCAACCAACCGCAGTAGAAGATTTGGAAGCAATAATTGACTATATCGCCAACCATAATACTGT
TGCCGCATATGACCTAGAAGACCATATTCTACAATCTGCTGAAGATTTGGCAGAACACCCATACAAAGGGCGTAATGGTC
GAAGAGCAGGAACAAGAGAGTTACTTGTCCATCCAAATTATTGGTTAGTCTATGAGGTTTCAGACCTGATTCGCATTACC
AATGTAATACATACGAGTAGACTCTATCCCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7305.11 Da        Isoelectric Point: 6.4663

>AT110894 WP_005404020.1 NZ_CP031987:2150-2338 [Acinetobacter haemolyticus]
MNTRFDPIVSEFESSDHEAEYNAWFIAKVEKSLADSRPTIPHDQVVARMKKRREEREANANR

Download         Length: 189 bp

>AT110894 NZ_CP031987:2150-2338 [Acinetobacter haemolyticus]
ATGAATACAAGGTTTGATCCTATCGTGTCAGAGTTTGAAAGTTCTGACCATGAAGCAGAATACAATGCGTGGTTTATTGC
AAAAGTTGAGAAATCACTAGCCGATTCACGCCCCACCATTCCCCATGACCAAGTAGTGGCACGTATGAAAAAACGTCGTG
AGGAAAGAGAAGCCAATGCTAATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8RH88

Antitoxin

Source ID Structure
AlphaFold DB A0A3R9RGY0

References