Detailed information of TA system TA110892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1623355..1624487
• Replicon: chromosome
• Accession: NZ_CP031984
• Organism: Acinetobacter haemolyticus strain AN3

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: AhaeAN3_RS07760
• Protein ID: WP_160127108.1
• Coordinates: 1623723..1624487 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: N9FA41
• Locus tag: AhaeAN3_RS07755
• Protein ID: WP_004639219.1
• Coordinates: 1623355..1623726 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN3_RS07725	1619446..1620030	-	585	WP_005090449.1	uracil-DNA glycosylase family protein	-
AhaeAN3_RS07730	1620157..1620417	-	261	WP_005080592.1	hypothetical protein	-
AhaeAN3_RS07735	1620557..1621255	-	699	WP_005080590.1	phosphoglycerate mutase family protein	-
AhaeAN3_RS07740	1621424..1622296	-	873	WP_075315624.1	MBL fold metallo-hydrolase	-
AhaeAN3_RS07745	1622311..1622724	-	414	WP_005090445.1	YeeE/YedE family protein	-
AhaeAN3_RS07750	1622726..1623139	-	414	WP_075315625.1	YeeE/YedE family protein	-
AhaeAN3_RS07755	1623355..1623726	+	372	WP_004639219.1	DUF2384 domain-containing protein	Antitoxin
AhaeAN3_RS07760	1623723..1624487	+	765	WP_160127108.1	RES family NAD+ phosphorylase	Toxin
AhaeAN3_RS07765	1624546..1625022	-	477	WP_005090442.1	hypothetical protein	-
AhaeAN3_RS07770	1625149..1625856	-	708	WP_017396078.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
AhaeAN3_RS07775	1625846..1626211	-	366	WP_004639223.1	cell division protein FtsB	-
AhaeAN3_RS07780	1626341..1627630	-	1290	WP_004639224.1	phosphopyruvate hydratase	-
AhaeAN3_RS07785	1627722..1628579	-	858	WP_004639225.1	3-deoxy-8-phosphooctulonate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (68-205)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (73-121)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29109.02 Da
• Isoelectric Point: 5.8003

>T110892 WP_160127108.1 NZ_CP031984:1623723-1624487 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWHSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGIEIFEYPSARASDHATCVGLFTAEHFNQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Nucleotide

• Length: 765 bp

>T110892 NZ_CP031984:1623723-1624487 [Acinetobacter haemolyticus]
ATGACTGCCATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACAAGGCAGTTAGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGATCACGTTTCGGCCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGCACTCAATGGATGGTGCACCAAAGAAAAAAACGATACGCACTGAGCATA
CTCTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATCTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGTACAGCAATGCGGAATGAAGGAATTGAGATCTTTGAGTATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAACCAGAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13291.58 Da
• Isoelectric Point: 10.4005

>AT110892 WP_004639219.1 NZ_CP031984:1623355-1623726 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Nucleotide

• Length: 372 bp

>AT110892 NZ_CP031984:1623355-1623726 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTGCTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTCGAGGTAAAGTATGA

Structures

Antitoxin

• AlphaFold DB: N9FA41