Detailed information of TA system TA110889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 305786..306406
• Replicon: chromosome
• Accession: NZ_CP031984
• Organism: Acinetobacter haemolyticus strain AN3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AhaeAN3_RS01435
• Protein ID: WP_008941148.1
• Coordinates: 305996..306406 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: AhaeAN3_RS01430
• Protein ID: WP_008941147.1
• Coordinates: 305786..305995 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN3_RS01400	301795..302007	+	213	WP_017395601.1	addiction module protein	-
AhaeAN3_RS01405	302004..302282	+	279	WP_075314557.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AhaeAN3_RS01410	302421..303311	+	891	WP_160126831.1	metal-dependent hydrolase	-
AhaeAN3_RS01415	303485..304075	+	591	WP_004641306.1	LemA family protein	-
AhaeAN3_RS01420	304098..305159	+	1062	WP_160126832.1	TPM domain-containing protein	-
AhaeAN3_RS01425	305153..305713	+	561	WP_160126833.1	TPM domain-containing protein	-
AhaeAN3_RS01430	305786..305995	+	210	WP_008941147.1	antitoxin	Antitoxin
AhaeAN3_RS01435	305996..306406	+	411	WP_008941148.1	tRNA(fMet)-specific endonuclease VapC	Toxin
AhaeAN3_RS01440	306556..307746	+	1191	WP_160126834.1	Fic family protein	-
AhaeAN3_RS01445	308102..308596	+	495	WP_160126835.1	pilin	-
AhaeAN3_RS01450	308909..309937	-	1029	WP_142028625.1	transposase	-
AhaeAN3_RS01455	310060..310794	+	735	WP_160126836.1	type IV pilin accessory protein	-
AhaeAN3_RS01460	310907..311137	+	231	WP_005088490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	308909..309955	1046

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15384.81 Da
• Isoelectric Point: 8.8849

>T110889 WP_008941148.1 NZ_CP031984:305996-306406 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTIKQRPLAVKERFNAVSTQLCISSITVAELIFGAENSQMPEKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRKGQPIGENDLHIAAHARSRGLILVTNNTREFERVPALQIENWLKESG

Nucleotide

• Length: 411 bp

>T110889 NZ_CP031984:305996-306406 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTTGATACCAATATTGTGATTTATACAATAAAACAAAGACCACTGGCGGTTAAAGAAAGGTTTAA
TGCTGTTTCAACACAACTTTGTATCAGTAGTATCACTGTTGCGGAATTAATTTTTGGGGCGGAAAATAGCCAAATGCCCG
AGAAGAATTTAAAAGTTGTAGAGGATTTTTTATCACGATTGCAAATTTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAAAAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACCAATAATACAAGAGAGTTTGAGCGTGTGCCTGCACTACAGATAGAAAACTGGTTGAAAG
AAAGCGGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT110889 WP_008941147.1 NZ_CP031984:305786-305995 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT110889 NZ_CP031984:305786-305995 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTAGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGTGGCGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8