Detailed information of TA system TA110888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 149463..150085
• Replicon: chromosome
• Accession: NZ_CP031984
• Organism: Acinetobacter haemolyticus strain AN3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AhaeAN3_RS00695
• Protein ID: WP_160126795.1
• Coordinates: 149463..149858 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJ14
• Locus tag: AhaeAN3_RS00700
• Protein ID: WP_075314389.1
• Coordinates: 149855..150085 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN3_RS00665	144875..145786	-	912	WP_005087216.1	alpha/beta hydrolase	-
AhaeAN3_RS00670	145976..146413	+	438	WP_100833059.1	DUF2147 domain-containing protein	-
AhaeAN3_RS00675	146510..146860	-	351	WP_100833060.1	Spx/MgsR family RNA polymerase-binding regulatory protein	-
AhaeAN3_RS00680	147300..148124	-	825	WP_008942133.1	exodeoxyribonuclease III	-
AhaeAN3_RS00685	148166..148816	+	651	WP_075314386.1	orotate phosphoribosyltransferase	-
AhaeAN3_RS00690	148875..149327	-	453	WP_100833061.1	ABZJ_00895 family protein	-
AhaeAN3_RS00695	149463..149858	-	396	WP_160126795.1	type II toxin-antitoxin system VapC family toxin	Toxin
AhaeAN3_RS00700	149855..150085	-	231	WP_075314389.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AhaeAN3_RS00705	150213..150932	-	720	WP_100833064.1	SDR family oxidoreductase	-
AhaeAN3_RS00710	151250..151777	+	528	WP_000537572.1	plasmid pRiA4b ORF-3 family protein	-
AhaeAN3_RS00720	153589..153891	+	303	WP_100834230.1	hypothetical protein	-
AhaeAN3_RS00725	154106..154420	+	315	WP_160126797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-37)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14899.14 Da
• Isoelectric Point: 6.7543

>T110888 WP_160126795.1 NZ_CP031984:c149858-149463 [Acinetobacter haemolyticus]
MIYLLDTNICIYVINHKPQHVFDRFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLDILAYDEHAIWHYA
KLRHDLQSAGKSIGNLDMLIAAHALAMDVVLVTNNTKEFERIDGLKLENWV

Nucleotide

• Length: 396 bp

>T110888 NZ_CP031984:c149858-149463 [Acinetobacter haemolyticus]
ATGATTTACCTCTTAGACACAAATATTTGTATCTATGTGATTAATCACAAACCTCAGCACGTCTTTGACCGATTTAAACA
GTATCAACTTGGTCAGCTTGCAATTTCGAGTATCACTGCATCTGAACTTGCTTTTGGTGTAGAAAAGTCTGGATCTGAAC
GCAATAAGCAGGCACTAAACAAATTTTTATCACCTTTAGACATCTTAGCTTATGATGAGCATGCTATTTGGCATTACGCT
AAATTACGCCATGATCTTCAATCGGCAGGTAAATCTATTGGTAACTTAGATATGTTGATAGCTGCCCATGCTTTAGCGAT
GGATGTTGTCTTAGTCACGAACAATACCAAAGAATTTGAACGTATTGATGGTCTAAAGTTAGAAAATTGGGTCTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8761.01 Da
• Isoelectric Point: 4.8141

>AT110888 WP_075314389.1 NZ_CP031984:c150085-149855 [Acinetobacter haemolyticus]
MEIAKVFKTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAVNEFEVGFQLERADQGEQEREEFR

Nucleotide

• Length: 231 bp

>AT110888 NZ_CP031984:c150085-149855 [Acinetobacter haemolyticus]
ATGGAAATTGCGAAAGTATTTAAAACAGGCCGAAGTCAGGCAGTTCGCTTGCCTAAAGCCTTCCGTTTTAATGGTACTGA
GGTCGCCATCAAAAGCTTTGGTCGTGGCGTGTTACTCATGCCCATCGACAATCCTTGGGATGTAATGTTAGAAGCTGTCA
ACGAATTTGAAGTTGGGTTCCAGTTAGAGCGAGCAGATCAAGGGGAACAAGAGCGTGAGGAATTTAGATGA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJ14