Detailed information of TA system TA110885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2189145..2189655
• Replicon: chromosome
• Accession: NZ_CP031979
• Organism: Acinetobacter haemolyticus strain AN4

Toxin (Protein)

• Gene name: relB
• Uniprot ID: N8PSJ1
• Locus tag: AhaeAN4_RS10765
• Protein ID: WP_004671840.1
• Coordinates: 2189392..2189655 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AhaeAN4_RS10760
• Protein ID: WP_125317037.1
• Coordinates: 2189145..2189408 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN4_RS10740	2184936..2185868	-	933	WP_020846310.1	IS5 family transposase	-
AhaeAN4_RS10745	2186190..2187338	+	1149	WP_125317038.1	inovirus-type Gp2 protein	-
AhaeAN4_RS10750	2187328..2188368	+	1041	WP_160124242.1	hypothetical protein	-
AhaeAN4_RS10755	2188462..2188728	+	267	WP_125317006.1	AlpA family phage regulatory protein	-
AhaeAN4_RS10760	2189145..2189408	+	264	WP_125317037.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AhaeAN4_RS10765	2189392..2189655	+	264	WP_004671840.1	Txe/YoeB family addiction module toxin	Toxin
AhaeAN4_RS10770	2190026..2191078	+	1053	WP_125317036.1	hypothetical protein	-
AhaeAN4_RS10775	2191164..2192372	-	1209	WP_125317005.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2184936..2264963	80027
	-	flank	IS/Tn	-	-	2184936..2185805	869

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10358.93 Da
• Isoelectric Point: 9.0098

>T110885 WP_004671840.1 NZ_CP031979:2189392-2189655 [Acinetobacter haemolyticus]
MKRKTSFTPTAWEDYVYWQSQDKKTLKRINTLIKECLRTPFEGIGKPEPLLGDLAGFWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T110885 NZ_CP031979:2189392-2189655 [Acinetobacter haemolyticus]
ATGAAACGGAAGACTAGTTTTACTCCAACAGCTTGGGAAGATTATGTGTACTGGCAAAGCCAAGACAAAAAAACGCTTAA
GCGCATCAATACATTAATCAAAGAGTGTCTTCGTACTCCCTTTGAAGGTATTGGCAAGCCTGAACCATTACTCGGTGATT
TAGCAGGTTTTTGGAGCAGGCGAATAGATGAGAAAAATAGATTAGTCTATGAAGTAACTGATGTAGCAATCACAATAATT
TCTTGTCGTTATCACTATGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9882.05 Da
• Isoelectric Point: 4.3176

>AT110885 WP_125317037.1 NZ_CP031979:2189145-2189408 [Acinetobacter haemolyticus]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLYLMSSPSNATHLAQSIAELRASKTIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT110885 NZ_CP031979:2189145-2189408 [Acinetobacter haemolyticus]
ATGCAAATTTTCACTTATACCGATGCTCGCAATAATCTGAAAACGGTTTTAGACCGTGTTATTGATGATTCAGATGTTGC
AGTAATTACGAGGAAAGAAGGTCAACATGCCGTTGTAATGGGACAAGACTATTACAACAGTATAATGGAAACATTGTACC
TCATGTCTTCTCCAAGTAACGCAACACACTTAGCGCAGTCAATTGCAGAGTTACGAGCGTCTAAAACAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A3Q8XJ07