110883

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1854697..1855829 Replicon chromosome
Accession NZ_CP031979
Organism Acinetobacter haemolyticus strain AN4

Toxin (Protein)


Gene name - Uniprot ID C0VPL6
Locus tag AhaeAN4_RS09110 Protein ID WP_004639220.1
Coordinates 1855065..1855829 (+) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag AhaeAN4_RS09105 Protein ID WP_004639219.1
Coordinates 1854697..1855068 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeAN4_RS09075 1850246..1850506 - 261 WP_005080592.1 hypothetical protein -
AhaeAN4_RS09080 1850645..1851343 - 699 WP_125316751.1 phosphoglycerate mutase family protein -
AhaeAN4_RS09085 1851463..1852455 + 993 WP_005028482.1 IS5-like element ISAba23 family transposase -
AhaeAN4_RS09090 1852766..1853638 - 873 WP_005080588.1 MBL fold metallo-hydrolase -
AhaeAN4_RS09095 1853653..1854066 - 414 WP_005090445.1 YeeE/YedE family protein -
AhaeAN4_RS09100 1854068..1854481 - 414 WP_005080585.1 YeeE/YedE family protein -
AhaeAN4_RS09105 1854697..1855068 + 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
AhaeAN4_RS09110 1855065..1855829 + 765 WP_004639220.1 RES family NAD+ phosphorylase Toxin
AhaeAN4_RS09115 1855888..1856364 - 477 WP_005090442.1 hypothetical protein -
AhaeAN4_RS09120 1856491..1857198 - 708 WP_004639222.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
AhaeAN4_RS09125 1857188..1857553 - 366 WP_004639223.1 cell division protein FtsB -
AhaeAN4_RS09130 1857683..1858972 - 1290 WP_004639224.1 phosphopyruvate hydratase -
AhaeAN4_RS09135 1859064..1859921 - 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1851463..1852455 992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29094.01 Da        Isoelectric Point: 5.5775

>T110883 WP_004639220.1 NZ_CP031979:1855065-1855829 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWYSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGVEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

>T110883 NZ_CP031979:1855065-1855829 [Acinetobacter haemolyticus]
ATGACCGCCATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACTAGGCAGTTGGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGGTCACGTTTCGGTCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGTACTCAATGGATGGTGCACCAAAGAAAAAAACGATACGCACTGAGCATA
CTTTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATCTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGTACAGCAATGCGGAATGAAGGAGTTGAGATCTTTGAGTATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAGCCAGAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT110883 WP_004639219.1 NZ_CP031979:1854697-1855068 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp

>AT110883 NZ_CP031979:1854697-1855068 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTACTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTAGAGGTAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A372MQ11

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References