Detailed information of TA system TA110882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1771766..1773402
• Replicon: chromosome
• Accession: NZ_CP031979
• Organism: Acinetobacter haemolyticus strain AN4

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A5P1UU42
• Locus tag: AhaeAN4_RS08755
• Protein ID: WP_005090545.1
• Coordinates: 1772071..1773402 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: AhaeAN4_RS08750
• Protein ID: WP_005090546.1
• Coordinates: 1771766..1772074 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN4_RS08720	1767367..1767558	-	192	WP_115736678.1	hypothetical protein	-
AhaeAN4_RS08725	1767691..1768977	+	1287	WP_160132125.1	DNA replication protein	-
AhaeAN4_RS08735	1770204..1770455	+	252	WP_125316755.1	hypothetical protein	-
AhaeAN4_RS08740	1770470..1770799	+	330	WP_125316754.1	hypothetical protein	-
AhaeAN4_RS08745	1771050..1771724	-	675	WP_005090547.1	DUF4145 domain-containing protein	-
AhaeAN4_RS08750	1771766..1772074	-	309	WP_005090546.1	helix-turn-helix domain-containing protein	Antitoxin
AhaeAN4_RS08755	1772071..1773402	-	1332	WP_005090545.1	HipA domain-containing protein	Toxin
AhaeAN4_RS08760	1773640..1774338	+	699	WP_005090543.1	DUF1826 domain-containing protein	-
AhaeAN4_RS08765	1774533..1775558	+	1026	WP_080631714.1	IS30-like element ISAba125 family transposase	-
AhaeAN4_RS08770	1775549..1776643	-	1095	WP_160132126.1	WG repeat-containing protein	-
AhaeAN4_RS08775	1776636..1777661	-	1026	WP_080631714.1	IS30-like element ISAba125 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1769009..1777646	8637

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-387)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 50765.55 Da
• Isoelectric Point: 4.8292

>T110882 WP_005090545.1 NZ_CP031979:c1773402-1772071 [Acinetobacter haemolyticus]
MQKLTIQALLDQNWLDIAELKLLEPKLGSASASELVYELEYAIQNLDKRDEHACSLSLPVQILINHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTYAEQDSILLEKGGIAPVGNLRIKEALPPINPDSTLHLRYFSQNDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWRNQCWQRHGLESVYSVLNKASGSHLNHFEVIDNLCDLLTVIDSNFDSTQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWEQITQKLAHLCDPNLSMKTLK
SLANNLVGLKQRLIDKGVPKQIMEMPALSFDYVEAKLERWELL

Nucleotide

• Length: 1332 bp

>T110882 NZ_CP031979:c1773402-1772071 [Acinetobacter haemolyticus]
ATGCAAAAATTAACAATACAGGCTTTACTCGACCAGAATTGGTTAGATATCGCTGAACTTAAACTATTAGAACCTAAGCT
GGGCTCAGCAAGCGCCAGTGAATTGGTCTACGAGTTGGAATACGCAATCCAAAATCTGGACAAGCGAGATGAACATGCCT
GTAGTCTCTCACTTCCTGTACAAATACTTATAAACCATGAATCTAGCTCATGGTTTGGTTTTTTGGATGATATTGTTCCT
TCAGGCGCAGCGCGCCGTTATTGGGTCAATTTTTTAGGCTTACAACGACTCACTTATGCTGAGCAAGATAGTATTTTATT
GGAAAAGGGTGGAATTGCGCCCGTAGGAAACTTGCGAATTAAAGAAGCTCTTCCGCCTATAAATCCTGACTCTACTTTGC
ATTTACGTTATTTTAGTCAAAATGATGTTGCTGATCGAAATGTTGATTTTCTTGAGTATGCACAGCAAATGGGCGCGATT
AGTGGTGGTGCAACAGGAGCGGGTGGTGAAGCGCCCAAGTTACTGATTCGCGCGACAAAAGATCAAAATATTTGGATTGA
CACCTATCAACAAAACTTTGATCAACCTGATCAACACTATTTAGTTAAATTTCCTCGAAATAATCGTAGTGAGATCGACT
GCAATATTCTCAGAGCGGAATACTATTACTATCAAGAACTAAAAGAATTAGGTTTCAATACCATTGAAACAACAGAAATG
AAGCTGATCGAAGGTGAAAAATATCCATCATTATGGTTGCCAAGATTTGATGTGGAATGGCGCAATCAATGTTGGCAACG
TCATGGTCTAGAATCTGTTTATTCAGTATTAAATAAGGCTTCAGGAAGTCATCTTAATCATTTTGAAGTAATAGACAACC
TATGTGATTTACTGACAGTGATTGATTCAAATTTTGATTCCACACAATTCGTTTGTGAATGGTTACAAAGAGACTTGCTC
AATATTATTTTTGGCAATTCTGATAATCACGGGCGAAATACCTCATTTCTAAAAAAATCTGGAAAAATTTCGCTTGCTCC
AATTTATGATTTTGCACCAATGAAAGCTGATCCAGAAGTCGTGACAAGATCAACGACATGGGGAAGTCCTTATGAAGAAG
GAGGAGAGTATCGTTGGGAGCAAATTACCCAGAAACTTGCACATTTATGCGATCCAAATTTGTCTATGAAGACATTAAAA
TCATTAGCAAACAATCTTGTTGGGCTAAAACAACGATTAATTGATAAAGGTGTCCCAAAACAGATTATGGAGATGCCAGC
ACTTTCATTCGATTATGTTGAAGCTAAATTAGAAAGATGGGAACTATTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11716.80 Da
• Isoelectric Point: 10.1562

>AT110882 WP_005090546.1 NZ_CP031979:c1772074-1771766 [Acinetobacter haemolyticus]
MNIKNQPQDRQKVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKLSE

Nucleotide

• Length: 309 bp

>AT110882 NZ_CP031979:c1772074-1771766 [Acinetobacter haemolyticus]
ATGAATATAAAAAATCAGCCTCAAGATCGCCAGAAAGTTCTTATTGATCTATATATGCAGTACTTATTGAATGAAATTAC
CTTAGGGCAATTATTGGCGTATTTGCGAAAAAATATACTTGGCATGTCTCAGGAACAATACGCAAATTTGGTCGGTGTCA
GTCGCAGAACATTAACGGACATAGAACAAGACAAAGGAAAACTCACGCAATCTGTTTTAGATAAAGTATTTAAACCACTG
GGATTGAAAGCAGGACTTGTACCGACTCATGAGCATATTGTGAGGAAGATTATTAAATTATCAGAGTGA

Structures

Toxin

• AlphaFold DB: A0A5P1UU42