Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1777779..1779415 Replicon chromosome
Accession NZ_CP031976
Organism Acinetobacter haemolyticus strain AN43

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AhaeAN43_RS08425 Protein ID WP_160126600.1
Coordinates 1777779..1779110 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AhaeAN43_RS08430 Protein ID WP_125501544.1
Coordinates 1779107..1779415 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeAN43_RS08405 1772896..1773777 - 882 WP_160126596.1 LysR family transcriptional regulator -
AhaeAN43_RS08410 1773953..1774384 - 432 WP_160126597.1 SRPBCC family protein -
AhaeAN43_RS08415 1774600..1776792 + 2193 WP_160126598.1 TonB-dependent siderophore receptor -
AhaeAN43_RS08420 1776843..1777541 - 699 WP_160126599.1 DUF1826 domain-containing protein -
AhaeAN43_RS08425 1777779..1779110 + 1332 WP_160126600.1 HipA domain-containing protein Toxin
AhaeAN43_RS08430 1779107..1779415 + 309 WP_125501544.1 helix-turn-helix domain-containing protein Antitoxin
AhaeAN43_RS08435 1779457..1780131 + 675 WP_160126601.1 DUF4145 domain-containing protein -
AhaeAN43_RS08440 1780383..1780649 + 267 Protein_1645 helix-turn-helix domain-containing protein -
AhaeAN43_RS08450 1781950..1783029 + 1080 Protein_1647 ISNCY family transposase -
AhaeAN43_RS08455 1783244..1784232 - 989 Protein_1648 AraC family transcriptional regulator ligand-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50753.62 Da        Isoelectric Point: 4.9532

>T110880 WP_160126600.1 NZ_CP031976:1777779-1779110 [Acinetobacter haemolyticus]
MQKLTIQALLDQNWLDIAELKILEPKLGSASASELVYKLEYAIQNLDKRDEHACSLSLPIQILINHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTYAEQDSILLEKGGIAPVGNLRIKEALPPINPDSTLHLRYFSQNDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQTDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWRNQCWQRHGLESVYSVLNKASGSHLNHFEVIDNLCDLLTVIDSNFDATQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWEQITQKLAHLCDPNLSMKTLK
SLASNLVGLKQRLIDKGVPKQIMEMPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T110880 NZ_CP031976:1777779-1779110 [Acinetobacter haemolyticus]
ATGCAAAAATTAACAATACAGGCTTTACTCGACCAGAATTGGTTAGACATCGCTGAACTTAAAATATTAGAACCTAAGCT
GGGCTCAGCAAGCGCCAGTGAATTGGTCTACAAGTTGGAATACGCAATCCAAAATCTGGATAAGCGGGATGAACATGCCT
GTAGTCTCTCACTACCTATACAAATACTTATAAACCATGAATCTAGCTCATGGTTTGGTTTTTTAGATGATATTGTTCCT
TCAGGTGCTGCACGCCGTTATTGGGTCAATTTTTTAGGCTTACAACGTCTCACTTATGCTGAGCAAGATAGTATTTTATT
GGAAAAGGGTGGAATTGCGCCCGTAGGAAACTTGAGAATTAAAGAAGCTCTTCCGCCTATAAATCCTGACTCTACTTTGC
ATTTACGTTATTTTAGTCAAAATGATGTTGCTGATCGAAATGTTGATTTTCTTGAGTATGCACAGCAAATGGGTGCAATT
AGTGGTGGTGCAACAGGAGCGGGTGGTGAAGCTCCTAAATTATTGATTCGTGCTACAAAAGATCAAAATATTTGGATTGA
TACTTATCAACAAAACTTTGATCAAACTGATCAACATTATCTAGTTAAGTTCCCTAGAAATAATCGTAGTGAGATCGACT
GTAATATTCTCAGAGCAGAATACTATTACTATCAAGAGCTAAAAGAGTTGGGTTTCAATACCATTGAAACTACAGAAATG
AAGCTCATTGAAGGTGAAAAATATCCATCATTATGGCTGCCAAGATTTGATGTGGAATGGCGCAATCAATGTTGGCAACG
TCATGGTCTAGAATCTGTTTATTCAGTATTAAATAAGGCTTCAGGAAGTCATCTTAATCATTTTGAAGTAATAGACAACC
TATGTGATTTACTGACAGTGATTGATTCAAATTTTGATGCTACACAATTCATTTGTGAATGGTTACAAAGAGATTTGCTC
AATATTATTTTTGGCAATTCTGATAATCACGGGCGAAATACCTCATTTCTAAAAAAATCTGGAAAAATTTCGCTTGCTCC
AATTTATGATTTTGCACCAATGAAAGCTGATCCAGAAGTCGTGACAAGATCAACGACCTGGGGAAGTCCTTATGAAGAAG
GAGGAGAGTATCGTTGGGAGCAAATTACCCAGAAACTTGCGCATTTATGCGATCCAAATTTGTCTATGAAGACATTAAAA
TCATTAGCAAGCAATCTTGTTGGGCTAAAACAACGGTTAATTGATAAAGGTGTCCCAAAACAGATTATGGAGATGCCAGC
ACTTTCATTCGATTATGTTGAAGCTAAATTAGAAAGATGGGAACTATTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11716.76 Da        Isoelectric Point: 9.9970

>AT110880 WP_125501544.1 NZ_CP031976:1779107-1779415 [Acinetobacter haemolyticus]
MNIKNQPQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKLSE

Download         Length: 309 bp

>AT110880 NZ_CP031976:1779107-1779415 [Acinetobacter haemolyticus]
ATGAATATAAAAAATCAGCCTCAAGATCGCCAGCAAGTTCTTATTGATCTATATATGCAGTACTTATTGAATGAAATTAC
CTTGGGGCAATTATTGGCATATTTGCGAAAAAATATACTTGGCATGTCTCAGGAACAATACGCAAATTTGGTTGGTGTCA
GTCGCAGAACATTAACGGACATAGAACAAGACAAAGGAAAACTCACGCAATCTGTCCTAGATAAAGTATTTAAACCACTG
GGATTGAAAGCAGGACTTGTACCGACTCATGAGCATATTGTGAGGAAGATTATTAAATTATCAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References