Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1690891..1692023 Replicon chromosome
Accession NZ_CP031976
Organism Acinetobacter haemolyticus strain AN43

Toxin (Protein)


Gene name - Uniprot ID C0VPL6
Locus tag AhaeAN43_RS08050 Protein ID WP_004639220.1
Coordinates 1690891..1691655 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag AhaeAN43_RS08055 Protein ID WP_004639219.1
Coordinates 1691652..1692023 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeAN43_RS08025 1686799..1687656 + 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -
AhaeAN43_RS08030 1687748..1689037 + 1290 WP_004639224.1 phosphopyruvate hydratase -
AhaeAN43_RS08035 1689167..1689532 + 366 WP_004639223.1 cell division protein FtsB -
AhaeAN43_RS08040 1689522..1690229 + 708 WP_004639222.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
AhaeAN43_RS08045 1690356..1690832 + 477 WP_005090442.1 hypothetical protein -
AhaeAN43_RS08050 1690891..1691655 - 765 WP_004639220.1 RES family NAD+ phosphorylase Toxin
AhaeAN43_RS08055 1691652..1692023 - 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
AhaeAN43_RS08060 1692239..1692520 + 282 Protein_1570 YeeE/YedE family protein -
AhaeAN43_RS08065 1692586..1693751 + 1166 WP_160126441.1 IS3 family transposase -
AhaeAN43_RS08075 1693931..1694344 + 414 WP_005090445.1 YeeE/YedE family protein -
AhaeAN43_RS08080 1694359..1695231 + 873 WP_005080588.1 MBL fold metallo-hydrolase -
AhaeAN43_RS08085 1695400..1696098 + 699 WP_005080590.1 phosphoglycerate mutase family protein -
AhaeAN43_RS08090 1696238..1696498 + 261 WP_005080592.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29094.01 Da        Isoelectric Point: 5.5775

>T110879 WP_004639220.1 NZ_CP031976:c1691655-1690891 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWYSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGVEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

>T110879 NZ_CP031976:c1691655-1690891 [Acinetobacter haemolyticus]
ATGACCGCCATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACTAGGCAGTTGGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGGTCACGTTTCGGTCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGTACTCAATGGATGGTGCACCAAAGAAAAAAACGATACGCACTGAGCATA
CTTTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATCTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGTACAGCAATGCGGAATGAAGGAGTTGAGATCTTTGAGTATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAGCCAGAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT110879 WP_004639219.1 NZ_CP031976:c1692023-1691652 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp

>AT110879 NZ_CP031976:c1692023-1691652 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTACTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTAGAGGTAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A372MQ11

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References