Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 516553..517192 Replicon chromosome
Accession NZ_CP031976
Organism Acinetobacter haemolyticus strain AN43

Toxin (Protein)


Gene name cptA Uniprot ID C0VNL5
Locus tag AhaeAN43_RS02500 Protein ID WP_005088316.1
Coordinates 516797..517192 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C0VNL4
Locus tag AhaeAN43_RS02495 Protein ID WP_005088318.1
Coordinates 516553..516810 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeAN43_RS02470 511626..511991 + 366 WP_004641032.1 50S ribosomal protein L17 -
AhaeAN43_RS02475 512156..512653 + 498 WP_004641030.1 GNAT family N-acetyltransferase -
AhaeAN43_RS02480 513032..514522 + 1491 WP_005086827.1 NAD(P)/FAD-dependent oxidoreductase -
AhaeAN43_RS02485 514645..515142 + 498 WP_005088321.1 DUF2059 domain-containing protein -
AhaeAN43_RS02490 515194..516366 - 1173 WP_005086825.1 acyl-CoA dehydrogenase family protein -
AhaeAN43_RS02495 516553..516810 + 258 WP_005088318.1 succinate dehydrogenase assembly factor 2 Antitoxin
AhaeAN43_RS02500 516797..517192 + 396 WP_005088316.1 hypothetical protein Toxin
AhaeAN43_RS02505 517403..517609 + 207 WP_026056364.1 hypothetical protein -
AhaeAN43_RS02510 517969..519012 + 1044 WP_004641019.1 hypothetical protein -
AhaeAN43_RS02515 519140..519721 + 582 WP_004641018.1 rhombosortase -
AhaeAN43_RS02520 519899..522109 + 2211 WP_004641016.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 16153.44 Da        Isoelectric Point: 9.1954

>T110877 WP_005088316.1 NZ_CP031976:516797-517192 [Acinetobacter haemolyticus]
MSTADRVFVLKRSRFAFAFQLFIFIVLISLLYYLLPWFLWLVSFPLMLIAWVLLLKQPQLKHFEYLDDQLCSLCFSDEMQ
RIEQRKIRKMIDHQCYIVIYFYDSQCRPCVIWWDQLSILQWKKLRTWVKLA

Download         Length: 396 bp

>T110877 NZ_CP031976:516797-517192 [Acinetobacter haemolyticus]
ATGTCCACGGCTGATCGTGTTTTTGTGTTGAAACGCAGTCGTTTTGCATTTGCGTTTCAACTTTTTATTTTTATCGTACT
GATCAGTTTATTGTATTACTTACTTCCTTGGTTTTTATGGCTTGTTAGCTTTCCTTTGATGCTAATTGCTTGGGTATTAT
TACTCAAACAACCTCAGCTTAAACACTTTGAATATTTAGATGATCAGCTTTGCTCCTTGTGTTTTAGTGATGAGATGCAG
AGGATCGAGCAAAGGAAAATTCGAAAAATGATCGATCATCAATGTTATATCGTCATCTATTTTTATGACTCTCAATGTCG
ACCTTGTGTGATTTGGTGGGATCAATTGTCGATTTTACAGTGGAAAAAGCTCAGAACATGGGTCAAACTTGCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10012.44 Da        Isoelectric Point: 4.4558

>AT110877 WP_005088318.1 NZ_CP031976:516553-516810 [Acinetobacter haemolyticus]
MSEELTLEERKVIYRARRGLKEIDVYFDPYVKNCYLTADATEKALFAELVDQEDPDLLDWFMEVGEPPRPELKAFISKLK
QYVHG

Download         Length: 258 bp

>AT110877 NZ_CP031976:516553-516810 [Acinetobacter haemolyticus]
ATGTCTGAAGAATTGACACTAGAAGAACGTAAAGTGATTTATCGTGCGCGTCGTGGTTTGAAAGAAATCGATGTGTATTT
TGATCCTTATGTCAAAAATTGTTATCTCACAGCAGATGCGACTGAGAAAGCATTGTTTGCAGAGTTGGTAGATCAAGAAG
ATCCTGATTTACTGGATTGGTTCATGGAGGTGGGTGAACCTCCTCGTCCAGAGTTAAAAGCGTTTATTTCAAAATTAAAA
CAGTATGTCCACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6KJV0

Antitoxin

Source ID Structure
AlphaFold DB A0A372MSY6

References