Detailed information of TA system TA110876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 383105..383725
• Replicon: chromosome
• Accession: NZ_CP031976
• Organism: Acinetobacter haemolyticus strain AN43

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AhaeAN43_RS01785
• Protein ID: WP_008941148.1
• Coordinates: 383315..383725 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: AhaeAN43_RS01780
• Protein ID: WP_008941147.1
• Coordinates: 383105..383314 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN43_RS01750	379111..379323	+	213	WP_017395601.1	addiction module protein	-
AhaeAN43_RS01755	379320..379598	+	279	WP_125502211.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AhaeAN43_RS01760	379737..380627	+	891	WP_017395603.1	metal-dependent hydrolase	-
AhaeAN43_RS01765	380801..381391	+	591	WP_004641306.1	LemA family protein	-
AhaeAN43_RS01770	381417..382478	+	1062	WP_125502209.1	TPM domain-containing protein	-
AhaeAN43_RS01775	382472..383032	+	561	WP_075314563.1	TPM domain-containing protein	-
AhaeAN43_RS01780	383105..383314	+	210	WP_008941147.1	antitoxin	Antitoxin
AhaeAN43_RS01785	383315..383725	+	411	WP_008941148.1	tRNA(fMet)-specific endonuclease VapC	Toxin
AhaeAN43_RS01790	383875..385065	+	1191	WP_160126455.1	Fic family protein	-
AhaeAN43_RS01795	385422..385916	+	495	WP_160126456.1	pilin	-
AhaeAN43_RS01800	385995..386249	+	255	WP_125502205.1	hypothetical protein	-
AhaeAN43_RS01805	386267..387001	+	735	WP_125502203.1	type IV pilin accessory protein	-
AhaeAN43_RS01810	387114..387344	+	231	WP_005088490.1	hypothetical protein	-
AhaeAN43_RS01815	387487..388032	+	546	WP_005088488.1	Uma2 family endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	350711..472312	121601

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15384.81 Da
• Isoelectric Point: 8.8849

>T110876 WP_008941148.1 NZ_CP031976:383315-383725 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTIKQRPLAVKERFNAVSTQLCISSITVAELIFGAENSQMPEKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRKGQPIGENDLHIAAHARSRGLILVTNNTREFERVPALQIENWLKESG

Nucleotide

• Length: 411 bp

>T110876 NZ_CP031976:383315-383725 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTCGATACCAATATTGTGATTTATACAATAAAACAAAGACCACTGGCGGTTAAAGAAAGGTTTAA
TGCTGTTTCAACACAACTTTGTATCAGTAGTATCACTGTTGCGGAATTAATTTTTGGGGCGGAAAATAGCCAAATGCCCG
AGAAGAATTTAAAAGTTGTAGAGGATTTTTTATCACGATTGCAAATTTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAAAAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACCAATAATACAAGAGAGTTTGAGCGTGTGCCTGCACTACAGATAGAAAACTGGTTGAAAG
AAAGCGGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT110876 WP_008941147.1 NZ_CP031976:383105-383314 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT110876 NZ_CP031976:383105-383314 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTAGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGTGGCGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8