Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1784513..1786149 Replicon chromosome
Accession NZ_CP031972
Organism Acinetobacter haemolyticus strain AN59

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AhaeAN59_RS08485 Protein ID WP_160126600.1
Coordinates 1784513..1785844 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AhaeAN59_RS08490 Protein ID WP_125501544.1
Coordinates 1785841..1786149 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeAN59_RS08465 1779630..1780511 - 882 WP_160126596.1 LysR family transcriptional regulator -
AhaeAN59_RS08470 1780687..1781118 - 432 WP_160126597.1 SRPBCC family protein -
AhaeAN59_RS08475 1781334..1783526 + 2193 WP_160126598.1 TonB-dependent siderophore receptor -
AhaeAN59_RS08480 1783577..1784275 - 699 WP_160126599.1 DUF1826 domain-containing protein -
AhaeAN59_RS08485 1784513..1785844 + 1332 WP_160126600.1 HipA domain-containing protein Toxin
AhaeAN59_RS08490 1785841..1786149 + 309 WP_125501544.1 helix-turn-helix domain-containing protein Antitoxin
AhaeAN59_RS08495 1786191..1786865 + 675 WP_160126601.1 DUF4145 domain-containing protein -
AhaeAN59_RS08500 1787117..1787383 + 267 Protein_1658 helix-turn-helix domain-containing protein -
AhaeAN59_RS08505 1787423..1788641 - 1219 Protein_1659 IS3-like element ISAba19 family transposase -
AhaeAN59_RS08510 1788683..1789762 + 1080 Protein_1660 ISNCY family transposase -
AhaeAN59_RS08515 1789851..1790792 - 942 WP_005090555.1 AraC family transcriptional regulator ligand-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50753.62 Da        Isoelectric Point: 4.9532

>T110875 WP_160126600.1 NZ_CP031972:1784513-1785844 [Acinetobacter haemolyticus]
MQKLTIQALLDQNWLDIAELKILEPKLGSASASELVYKLEYAIQNLDKRDEHACSLSLPIQILINHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTYAEQDSILLEKGGIAPVGNLRIKEALPPINPDSTLHLRYFSQNDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQTDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWRNQCWQRHGLESVYSVLNKASGSHLNHFEVIDNLCDLLTVIDSNFDATQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWEQITQKLAHLCDPNLSMKTLK
SLASNLVGLKQRLIDKGVPKQIMEMPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T110875 NZ_CP031972:1784513-1785844 [Acinetobacter haemolyticus]
ATGCAAAAATTAACAATACAGGCTTTACTCGACCAGAATTGGTTAGACATCGCTGAACTTAAAATATTAGAACCTAAGCT
GGGCTCAGCAAGCGCCAGTGAATTGGTCTACAAGTTGGAATACGCAATCCAAAATCTGGATAAGCGGGATGAACATGCCT
GTAGTCTCTCACTACCTATACAAATACTTATAAACCATGAATCTAGCTCATGGTTTGGTTTTTTAGATGATATTGTTCCT
TCAGGTGCTGCACGCCGTTATTGGGTCAATTTTTTAGGCTTACAACGTCTCACTTATGCTGAGCAAGATAGTATTTTATT
GGAAAAGGGTGGAATTGCGCCCGTAGGAAACTTGAGAATTAAAGAAGCTCTTCCGCCTATAAATCCTGACTCTACTTTGC
ATTTACGTTATTTTAGTCAAAATGATGTTGCTGATCGAAATGTTGATTTTCTTGAGTATGCACAGCAAATGGGTGCAATT
AGTGGTGGTGCAACAGGAGCGGGTGGTGAAGCTCCTAAATTATTGATTCGTGCTACAAAAGATCAAAATATTTGGATTGA
TACTTATCAACAAAACTTTGATCAAACTGATCAACATTATCTAGTTAAGTTCCCTAGAAATAATCGTAGTGAGATCGACT
GTAATATTCTCAGAGCAGAATACTATTACTATCAAGAGCTAAAAGAGTTGGGTTTCAATACCATTGAAACTACAGAAATG
AAGCTCATTGAAGGTGAAAAATATCCATCATTATGGCTGCCAAGATTTGATGTGGAATGGCGCAATCAATGTTGGCAACG
TCATGGTCTAGAATCTGTTTATTCAGTATTAAATAAGGCTTCAGGAAGTCATCTTAATCATTTTGAAGTAATAGACAACC
TATGTGATTTACTGACAGTGATTGATTCAAATTTTGATGCTACACAATTCATTTGTGAATGGTTACAAAGAGATTTGCTC
AATATTATTTTTGGCAATTCTGATAATCACGGGCGAAATACCTCATTTCTAAAAAAATCTGGAAAAATTTCGCTTGCTCC
AATTTATGATTTTGCACCAATGAAAGCTGATCCAGAAGTCGTGACAAGATCAACGACCTGGGGAAGTCCTTATGAAGAAG
GAGGAGAGTATCGTTGGGAGCAAATTACCCAGAAACTTGCGCATTTATGCGATCCAAATTTGTCTATGAAGACATTAAAA
TCATTAGCAAGCAATCTTGTTGGGCTAAAACAACGGTTAATTGATAAAGGTGTCCCAAAACAGATTATGGAGATGCCAGC
ACTTTCATTCGATTATGTTGAAGCTAAATTAGAAAGATGGGAACTATTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11716.76 Da        Isoelectric Point: 9.9970

>AT110875 WP_125501544.1 NZ_CP031972:1785841-1786149 [Acinetobacter haemolyticus]
MNIKNQPQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKLSE

Download         Length: 309 bp

>AT110875 NZ_CP031972:1785841-1786149 [Acinetobacter haemolyticus]
ATGAATATAAAAAATCAGCCTCAAGATCGCCAGCAAGTTCTTATTGATCTATATATGCAGTACTTATTGAATGAAATTAC
CTTGGGGCAATTATTGGCATATTTGCGAAAAAATATACTTGGCATGTCTCAGGAACAATACGCAAATTTGGTTGGTGTCA
GTCGCAGAACATTAACGGACATAGAACAAGACAAAGGAAAACTCACGCAATCTGTCCTAGATAAAGTATTTAAACCACTG
GGATTGAAAGCAGGACTTGTACCGACTCATGAGCATATTGTGAGGAAGATTATTAAATTATCAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References