Detailed information of TA system TA110871

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 384219..384839
• Replicon: chromosome
• Accession: NZ_CP031972
• Organism: Acinetobacter haemolyticus strain AN59

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AhaeAN59_RS01790
• Protein ID: WP_008941148.1
• Coordinates: 384429..384839 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: AhaeAN59_RS01785
• Protein ID: WP_008941147.1
• Coordinates: 384219..384428 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN59_RS01755	380225..380437	+	213	WP_017395601.1	addiction module protein	-
AhaeAN59_RS01760	380434..380712	+	279	WP_125502211.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AhaeAN59_RS01765	380851..381741	+	891	WP_017395603.1	metal-dependent hydrolase	-
AhaeAN59_RS01770	381915..382505	+	591	WP_004641306.1	LemA family protein	-
AhaeAN59_RS01775	382531..383592	+	1062	WP_125502209.1	TPM domain-containing protein	-
AhaeAN59_RS01780	383586..384146	+	561	WP_075314563.1	TPM domain-containing protein	-
AhaeAN59_RS01785	384219..384428	+	210	WP_008941147.1	antitoxin	Antitoxin
AhaeAN59_RS01790	384429..384839	+	411	WP_008941148.1	tRNA(fMet)-specific endonuclease VapC	Toxin
AhaeAN59_RS01795	384989..386179	+	1191	WP_160126455.1	Fic family protein	-
AhaeAN59_RS01800	386536..387030	+	495	WP_160126456.1	pilin	-
AhaeAN59_RS01805	387109..387363	+	255	WP_125502205.1	hypothetical protein	-
AhaeAN59_RS01810	387381..388115	+	735	WP_125502203.1	type IV pilin accessory protein	-
AhaeAN59_RS01815	388228..388458	+	231	WP_005088490.1	hypothetical protein	-
AhaeAN59_RS01820	388601..389146	+	546	WP_005088488.1	Uma2 family endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15384.81 Da
• Isoelectric Point: 8.8849

>T110871 WP_008941148.1 NZ_CP031972:384429-384839 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTIKQRPLAVKERFNAVSTQLCISSITVAELIFGAENSQMPEKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRKGQPIGENDLHIAAHARSRGLILVTNNTREFERVPALQIENWLKESG

Nucleotide

• Length: 411 bp

>T110871 NZ_CP031972:384429-384839 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTCGATACCAATATTGTGATTTATACAATAAAACAAAGACCACTGGCGGTTAAAGAAAGGTTTAA
TGCTGTTTCAACACAACTTTGTATCAGTAGTATCACTGTTGCGGAATTAATTTTTGGGGCGGAAAATAGCCAAATGCCCG
AGAAGAATTTAAAAGTTGTAGAGGATTTTTTATCACGATTGCAAATTTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAAAAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACCAATAATACAAGAGAGTTTGAGCGTGTGCCTGCACTACAGATAGAAAACTGGTTGAAAG
AAAGCGGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT110871 WP_008941147.1 NZ_CP031972:384219-384428 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT110871 NZ_CP031972:384219-384428 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTAGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGTGGCGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8