Detailed information of TA system TA110870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1416531..1417200
• Replicon: chromosome
• Accession: NZ_CP031970
• Organism: Streptococcus suis strain SFJ44

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G7SGM1
• Locus tag: D2A30_RS07255
• Protein ID: WP_014637653.1
• Coordinates: 1417018..1417200 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: D2A30_RS07250
• Protein ID: WP_239604090.1
• Coordinates: 1416531..1416980 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D2A30_RS07235 (D2A30_07400)	1411662..1414124	-	2463	WP_239604087.1	heavy metal translocating P-type ATPase	-
D2A30_RS07240 (D2A30_07405)	1414219..1415076	-	858	WP_239604088.1	SAM-dependent methyltransferase TehB	-
D2A30_RS07245 (D2A30_07410)	1415329..1416372	+	1044	WP_239604089.1	alcohol dehydrogenase catalytic domain-containing protein	-
D2A30_RS07250 (D2A30_07415)	1416531..1416980	-	450	WP_239604090.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
D2A30_RS07255 (D2A30_07420)	1417018..1417200	-	183	WP_014637653.1	type II toxin-antitoxin system HicA family toxin	Toxin
D2A30_RS07260 (D2A30_07425)	1417577..1418044	-	468	WP_171989832.1	SsrA-binding protein SmpB	-
D2A30_RS07265 (D2A30_07430)	1418047..1420416	-	2370	WP_239604091.1	ribonuclease R	-
D2A30_RS07270 (D2A30_07435)	1420680..1420913	-	234	WP_171989834.1	preprotein translocase subunit SecG	-
D2A30_RS07275 (D2A30_07440)	1420960..1421109	-	150	WP_012775228.1	50S ribosomal protein L33	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-113)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6653.87 Da
• Isoelectric Point: 10.8207

>T110870 WP_014637653.1 NZ_CP031970:c1417200-1417018 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 183 bp

>T110870 NZ_CP031970:c1417200-1417018 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCCATAACCATTCCCCACGGTGAAATAAACAAATATACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16620.60 Da
• Isoelectric Point: 3.9788

>AT110870 WP_239604090.1 NZ_CP031970:c1416980-1416531 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
HDEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 450 bp

>AT110870 NZ_CP031970:c1416980-1416531 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCGCCCTACTTTGTAACATTCCCTGA
TTTTGAGCATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATCGAGAATGGACGAGACATTCCTACCCCGTCTTCTATAAATACTTTGTCATTAGTAGATAATAACCCTTTC
CATGATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGATGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGACACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAGATCCATGCTTAA

Structures

Toxin

• AlphaFold DB: G7SGM1