Detailed information of TA system TA110868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1376406..1377031
• Replicon: chromosome
• Accession: NZ_CP031970
• Organism: Streptococcus suis strain SFJ44

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D2A30_RS07060
• Protein ID: WP_171989763.1
• Coordinates: 1376406..1376744 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: D2A30_RS07065
• Protein ID: WP_130554939.1
• Coordinates: 1376744..1377031 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D2A30_RS07035 (D2A30_07195)	1372297..1373271	-	975	WP_239604061.1	YvcK family protein	-
D2A30_RS07040 (D2A30_07200)	1373268..1374155	-	888	WP_239604062.1	RNase adapter RapZ	-
D2A30_RS07045 (D2A30_07205)	1374178..1374558	-	381	WP_171989760.1	RidA family protein	-
D2A30_RS07050 (D2A30_07210)	1374608..1375927	-	1320	WP_239604063.1	MATE family efflux transporter	-
D2A30_RS07055 (D2A30_07220)	1376222..1376425	-	204	WP_239604064.1	LPXTG cell wall anchor domain-containing protein	-
D2A30_RS07060 (D2A30_07225)	1376406..1376744	-	339	WP_171989763.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D2A30_RS07065 (D2A30_07230)	1376744..1377031	-	288	WP_130554939.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D2A30_RS07070 (D2A30_07235)	1377186..1377455	-	270	WP_239604065.1	type II toxin-antitoxin system RelE/ParE family toxin	-
D2A30_RS07075 (D2A30_07240)	1377445..1377672	-	228	WP_130554954.1	DUF6290 family protein	-
D2A30_RS07080 (D2A30_07245)	1377825..1379171	-	1347	WP_216806577.1	asparagine--tRNA ligase	-
D2A30_RS07085 (D2A30_07250)	1379186..1380367	-	1182	WP_171989765.1	pyridoxal phosphate-dependent aminotransferase	-
D2A30_RS07090 (D2A30_07255)	1380364..1380861	-	498	WP_171989766.1	DUF5590 domain-containing protein	-
D2A30_RS07095 (D2A30_07260)	1381008..1381448	+	441	WP_130554934.1	MarR family winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-106)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-81)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12914.84 Da
• Isoelectric Point: 5.9262

>T110868 WP_171989763.1 NZ_CP031970:c1376744-1376406 [Streptococcus suis]
MEKYRVIISPKLIEQIKSIRDYVANVKLSPETAERLVTAIFDEIESLELFPERGFDADEKIGVKIDKNGRSSRGITIQNG
KYIVIYTVNQEEHLVEVAFLFSSKTDYAKLFR

Nucleotide

• Length: 339 bp

>T110868 NZ_CP031970:c1376744-1376406 [Streptococcus suis]
ATGGAGAAATATAGAGTCATTATTTCGCCAAAGCTTATTGAGCAAATCAAAAGTATTAGGGATTATGTTGCTAATGTGAA
ACTGAGTCCAGAAACTGCAGAGCGTTTAGTAACGGCAATTTTTGATGAAATAGAGAGCCTAGAACTCTTTCCAGAGCGTG
GATTCGATGCTGATGAAAAAATTGGAGTTAAGATTGATAAGAATGGCCGTAGTAGCCGAGGAATAACCATTCAAAATGGA
AAATATATTGTCATCTATACTGTAAACCAGGAAGAGCATTTAGTTGAAGTTGCTTTCCTATTCTCATCAAAGACTGATTA
TGCTAAACTTTTTCGATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10811.34 Da
• Isoelectric Point: 4.7494

>AT110868 WP_130554939.1 NZ_CP031970:c1377031-1376744 [Streptococcus suis]
MPTVIRDKQINFKVNSEYFELAKVVFQENGLDITSAFNEFVQEVAISKTLPFKTVEEKEREKLIARLQEEVSTSYEALKA
DKGLSVEEARKAVLG

Nucleotide

• Length: 288 bp

>AT110868 NZ_CP031970:c1377031-1376744 [Streptococcus suis]
ATGCCAACAGTAATAAGGGATAAACAAATCAACTTCAAAGTAAATTCAGAATACTTTGAATTAGCGAAAGTGGTCTTTCA
GGAAAACGGACTGGATATTACATCAGCATTCAATGAATTTGTACAAGAGGTCGCAATTTCCAAAACACTGCCTTTTAAGA
CAGTAGAGGAAAAGGAGAGAGAGAAGTTAATTGCTCGACTTCAAGAAGAAGTTTCCACTAGCTATGAAGCGCTAAAAGCA
GATAAAGGGTTGTCGGTTGAGGAAGCGAGAAAGGCAGTACTAGGATAA