Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1018386..1018872 Replicon chromosome
Accession NZ_CP031970
Organism Streptococcus suis strain SFJ44

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D2A30_RS05220 Protein ID WP_239603896.1
Coordinates 1018386..1018643 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D2A30_RS05225 Protein ID WP_105142535.1
Coordinates 1018633..1018872 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D2A30_RS05200 (D2A30_05340) 1013705..1014775 + 1071 WP_171988517.1 tyrosine recombinase XerS -
D2A30_RS05205 (D2A30_05345) 1015053..1016561 - 1509 WP_239603893.1 phosphomannomutase/phosphoglucomutase -
D2A30_RS05210 (D2A30_05355) 1016742..1017683 - 942 WP_239603894.1 sensor histidine kinase -
D2A30_RS05215 (D2A30_05360) 1017680..1018348 - 669 WP_239603895.1 response regulator transcription factor -
D2A30_RS05220 (D2A30_05365) 1018386..1018643 - 258 WP_239603896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D2A30_RS05225 (D2A30_05370) 1018633..1018872 - 240 WP_105142535.1 DUF6290 family protein Antitoxin
D2A30_RS05230 (D2A30_05375) 1018963..1020933 - 1971 WP_239603897.1 ABC transporter permease -
D2A30_RS05235 (D2A30_05380) 1020934..1021686 - 753 WP_171988480.1 ABC transporter ATP-binding protein -
D2A30_RS05240 (D2A30_05385) 1021695..1022084 - 390 WP_239603898.1 NisI/SpaI family lantibiotic immunity lipoprotein -
D2A30_RS05245 (D2A30_05390) 1022097..1022237 - 141 WP_239603899.1 hypothetical protein -
D2A30_RS05250 (D2A30_05395) 1022376..1023542 - 1167 WP_239603900.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) / tetA(P) - 968386..1041508 73122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-74)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9899.62 Da        Isoelectric Point: 10.6957

>T110867 WP_239603896.1 NZ_CP031970:c1018643-1018386 [Streptococcus suis]
MSYKVILSARVQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGIALTANRSGQWRYRIGNYRVIVSIEDDKVIMTSIKM
RNGSM

Download         Length: 258 bp

>T110867 NZ_CP031970:c1018643-1018386 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAGGGTTCAAAAGCAAATTCGAAAAATGGATAAAACGGCTGCAAGTTTGATTTT
GCGGTATCTTTATAAGCATATCGACGGGTGCGACAACCCTAGACAATACGGAATAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAAGTGATTATGACAAGCATAAAAATG
AGAAATGGAAGTATGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8763.02 Da        Isoelectric Point: 3.8548

>AT110867 WP_105142535.1 NZ_CP031970:c1018872-1018633 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLAALEDEYDARVADIAWAEYQADLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT110867 NZ_CP031970:c1018872-1018633 [Streptococcus suis]
ATGGCAGCTATTACATTAAAAGTTTCTGAGCAAGACAAGCTATTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGCTT
GTCAGAACTCATCCGGACTAAAACCCTTGCAGCTCTCGAAGATGAATACGATGCCCGCGTGGCAGATATTGCTTGGGCAG
AATACCAAGCTGACTTGGCGAATGGAATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References