Detailed information of TA system TA110867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1018386..1018872
• Replicon: chromosome
• Accession: NZ_CP031970
• Organism: Streptococcus suis strain SFJ44

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D2A30_RS05220
• Protein ID: WP_239603896.1
• Coordinates: 1018386..1018643 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D2A30_RS05225
• Protein ID: WP_105142535.1
• Coordinates: 1018633..1018872 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D2A30_RS05200 (D2A30_05340)	1013705..1014775	+	1071	WP_171988517.1	tyrosine recombinase XerS	-
D2A30_RS05205 (D2A30_05345)	1015053..1016561	-	1509	WP_239603893.1	phosphomannomutase/phosphoglucomutase	-
D2A30_RS05210 (D2A30_05355)	1016742..1017683	-	942	WP_239603894.1	sensor histidine kinase	-
D2A30_RS05215 (D2A30_05360)	1017680..1018348	-	669	WP_239603895.1	response regulator transcription factor	-
D2A30_RS05220 (D2A30_05365)	1018386..1018643	-	258	WP_239603896.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D2A30_RS05225 (D2A30_05370)	1018633..1018872	-	240	WP_105142535.1	DUF6290 family protein	Antitoxin
D2A30_RS05230 (D2A30_05375)	1018963..1020933	-	1971	WP_239603897.1	ABC transporter permease	-
D2A30_RS05235 (D2A30_05380)	1020934..1021686	-	753	WP_171988480.1	ABC transporter ATP-binding protein	-
D2A30_RS05240 (D2A30_05385)	1021695..1022084	-	390	WP_239603898.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
D2A30_RS05245 (D2A30_05390)	1022097..1022237	-	141	WP_239603899.1	hypothetical protein	-
D2A30_RS05250 (D2A30_05395)	1022376..1023542	-	1167	WP_239603900.1	ATP-grasp domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M) / tetA(P)	-	968386..1041508	73122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-74)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9899.62 Da
• Isoelectric Point: 10.6957

>T110867 WP_239603896.1 NZ_CP031970:c1018643-1018386 [Streptococcus suis]
MSYKVILSARVQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGIALTANRSGQWRYRIGNYRVIVSIEDDKVIMTSIKM
RNGSM

Nucleotide

• Length: 258 bp

>T110867 NZ_CP031970:c1018643-1018386 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAGGGTTCAAAAGCAAATTCGAAAAATGGATAAAACGGCTGCAAGTTTGATTTT
GCGGTATCTTTATAAGCATATCGACGGGTGCGACAACCCTAGACAATACGGAATAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAAGTGATTATGACAAGCATAAAAATG
AGAAATGGAAGTATGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8763.02 Da
• Isoelectric Point: 3.8548

>AT110867 WP_105142535.1 NZ_CP031970:c1018872-1018633 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLAALEDEYDARVADIAWAEYQADLANGIEPITLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT110867 NZ_CP031970:c1018872-1018633 [Streptococcus suis]
ATGGCAGCTATTACATTAAAAGTTTCTGAGCAAGACAAGCTATTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGCTT
GTCAGAACTCATCCGGACTAAAACCCTTGCAGCTCTCGAAGATGAATACGATGCCCGCGTGGCAGATATTGCTTGGGCAG
AATACCAAGCTGACTTGGCGAATGGAATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA