Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 5624689..5625314 Replicon chromosome
Accession NZ_CP031969
Organism Streptomyces sp. CC0208

Toxin (Protein)


Gene name vapC Uniprot ID B5HNI6
Locus tag D1369_RS25900 Protein ID WP_007382245.1
Coordinates 5624895..5625314 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B5HNI7
Locus tag D1369_RS25895 Protein ID WP_007382246.1
Coordinates 5624689..5624898 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1369_RS25885 5620147..5620458 + 312 WP_007382248.1 hypothetical protein -
D1369_RS25890 5620442..5624623 + 4182 WP_158680127.1 trypsin-like peptidase domain-containing protein -
D1369_RS25895 5624689..5624898 + 210 WP_007382246.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
D1369_RS25900 5624895..5625314 + 420 WP_007382245.1 PIN domain nuclease Toxin
D1369_RS25905 5625389..5626831 - 1443 WP_007382244.1 beta-glucosidase -
D1369_RS25910 5626949..5627857 - 909 WP_007382243.1 carbohydrate ABC transporter permease -
D1369_RS25915 5627869..5628882 - 1014 WP_007382242.1 sugar ABC transporter permease -
D1369_RS25920 5628888..5630219 - 1332 WP_007382241.1 extracellular solute-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15481.45 Da        Isoelectric Point: 4.5244

>T110865 WP_007382245.1 NZ_CP031969:5624895-5625314 [Streptomyces sp. CC0208]
MSATAYLIDTSALVRILKHPARPRWEKPLEEGLISRCPMTEVEFLYSARNAEDRSELVQDLDALFGWTPLDDRAVSRAWD
VQRELTEKGQHRSAGAVDLLVAATAELQGLTMLHYDNDFETIASVTGQPTQWLAAPGSL

Download         Length: 420 bp

>T110865 NZ_CP031969:5624895-5625314 [Streptomyces sp. CC0208]
ATGAGCGCGACCGCCTACCTCATCGACACCAGCGCGCTGGTCCGCATCCTGAAACACCCCGCCCGTCCCCGATGGGAAAA
ACCCCTGGAAGAGGGGCTCATCTCGCGCTGCCCCATGACGGAGGTCGAGTTCCTCTACAGCGCCCGGAACGCCGAGGACC
GGTCCGAGCTGGTCCAGGACCTGGACGCGTTGTTCGGCTGGACGCCACTGGACGACCGGGCCGTGTCCCGGGCCTGGGAC
GTGCAGCGTGAGCTCACCGAGAAGGGGCAGCACCGCTCCGCCGGAGCCGTGGACCTCCTCGTCGCCGCGACGGCCGAACT
GCAAGGGCTGACCATGCTCCACTACGACAACGACTTCGAGACCATCGCCTCGGTCACAGGACAGCCGACCCAGTGGCTCG
CGGCGCCGGGCAGTCTCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7718.82 Da        Isoelectric Point: 8.6147

>AT110865 WP_007382246.1 NZ_CP031969:5624689-5624898 [Streptomyces sp. CC0208]
MTKTLIDIDEQLLAEAAIAFGTRTKKDTVNAALREGVERKKRALALARLAARADAGDFDELLDKENYRR

Download         Length: 210 bp

>AT110865 NZ_CP031969:5624689-5624898 [Streptomyces sp. CC0208]
ATGACCAAGACCCTGATCGACATCGACGAGCAACTCCTGGCCGAGGCGGCCATAGCGTTCGGTACCAGGACCAAGAAGGA
CACGGTCAATGCCGCGCTGAGGGAGGGCGTCGAGCGCAAGAAGCGGGCGCTCGCCCTCGCCAGGCTCGCGGCGCGGGCCG
ACGCGGGGGACTTCGACGAGTTGCTCGACAAGGAGAACTACCGTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7K2PLZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A7K2PM24

References