Detailed information of TA system TA110864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 4660393..4660930
• Replicon: chromosome
• Accession: NZ_CP031969
• Organism: Streptomyces sp. CC0208

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7K2PPF8
• Locus tag: D1369_RS21355
• Protein ID: WP_037903439.1
• Coordinates: 4660646..4660930 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D1369_RS21350
• Protein ID: WP_106433606.1
• Coordinates: 4660393..4660641 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1369_RS21325	4655594..4657468	+	1875	WP_007383111.1	copper resistance protein CopC/CopD	-
D1369_RS21330	4657434..4658312	-	879	WP_007383110.1	DUF72 domain-containing protein	-
D1369_RS21335	4658344..4659123	+	780	WP_007383109.1	SDR family oxidoreductase	-
D1369_RS21345	4659361..4660146	+	786	Protein_4163	helix-turn-helix transcriptional regulator	-
D1369_RS21350	4660393..4660641	+	249	WP_106433606.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1369_RS21355	4660646..4660930	+	285	WP_037903439.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1369_RS21360	4661312..4663873	-	2562	WP_007383105.1	tetratricopeptide repeat protein	-
D1369_RS21365	4663896..4664183	-	288	WP_007383104.1	hypothetical protein	-
D1369_RS21370	4664960..4665406	+	447	WP_202477028.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-62)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10881.58 Da
• Isoelectric Point: 10.8200

>T110864 WP_037903439.1 NZ_CP031969:4660646-4660930 [Streptomyces sp. CC0208]
MGYVTRFTPHAQRNMLKVPRPDARRILYRLAELQKALDAGDTASFDIKALQGHSARWRLRVGDYRVVYTVEDGQLIVWVL
VAVGNRRDVYRQVP

Nucleotide

• Length: 285 bp

>T110864 NZ_CP031969:4660646-4660930 [Streptomyces sp. CC0208]
ATGGGGTACGTCACGCGCTTCACACCGCACGCCCAGCGGAACATGCTCAAGGTCCCGCGCCCGGATGCCCGGCGCATTCT
GTATCGCCTCGCCGAACTCCAGAAGGCGCTGGACGCCGGCGACACCGCCTCGTTCGACATCAAGGCCCTCCAGGGGCACA
GCGCCCGCTGGCGACTCAGGGTCGGCGACTACCGCGTTGTCTACACCGTTGAGGACGGCCAGCTGATCGTGTGGGTCCTG
GTGGCCGTCGGCAACCGTCGCGACGTCTACCGCCAAGTTCCGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9464.59 Da
• Isoelectric Point: 4.5942

>AT110864 WP_106433606.1 NZ_CP031969:4660393-4660641 [Streptomyces sp. CC0208]
MADVRSHLADVIDRARREGTPTIITRRGKQEAVVIDIQEYQRLREIVENAEEAWLNRLADEAESEGSVSLEEMARMLRAD
QR

Nucleotide

• Length: 249 bp

>AT110864 NZ_CP031969:4660393-4660641 [Streptomyces sp. CC0208]
ATGGCGGATGTCCGCAGTCACCTCGCTGACGTCATTGATCGCGCCCGGCGGGAGGGAACCCCGACGATCATCACTCGGCG
TGGTAAGCAGGAGGCCGTCGTGATCGACATCCAGGAGTACCAGCGCCTGCGTGAGATCGTGGAGAACGCCGAGGAGGCGT
GGCTCAACCGGCTGGCCGACGAAGCCGAGTCGGAGGGGTCGGTCTCGCTCGAAGAGATGGCCCGCATGCTGCGTGCCGAT
CAGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A7K2PPF8