Detailed information of TA system TA110860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1265565..1266167
• Replicon: chromosome
• Accession: NZ_CP031968
• Organism: Chromobacterium rhizoryzae strain JP2-74

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0J6MTI0
• Locus tag: D1345_RS05770
• Protein ID: WP_043634155.1
• Coordinates: 1265565..1265747 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: D1345_RS05775
• Protein ID: WP_107731681.1
• Coordinates: 1265757..1266167 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1345_RS05750	1260976..1261689	-	714	WP_118266766.1	ABC transporter permease subunit	-
D1345_RS05755	1261730..1262503	-	774	WP_118266768.1	transporter substrate-binding domain-containing protein	-
D1345_RS05760	1262523..1263314	-	792	WP_118266770.1	ATP-binding cassette domain-containing protein	-
D1345_RS05765	1263869..1265281	+	1413	WP_081556622.1	sigma 54-interacting transcriptional regulator	-
D1345_RS05770	1265565..1265747	+	183	WP_043634155.1	type II toxin-antitoxin system HicA family toxin	Toxin
D1345_RS05775	1265757..1266167	+	411	WP_107731681.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
D1345_RS05780	1266508..1267446	-	939	WP_107731682.1	PDR/VanB family oxidoreductase	-
D1345_RS05785	1267462..1268607	-	1146	WP_107731683.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
D1345_RS05790	1268844..1269725	+	882	WP_107733049.1	GlxA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6578.73 Da
• Isoelectric Point: 10.7364

>T110860 WP_043634155.1 NZ_CP031968:1265565-1265747 [Chromobacterium rhizoryzae]
VTSKEVISMIEADGWYLVAAKGSHQQFKHPIKTGRVTVPHPKKDIPIGTLNSIKKQAGLK

Nucleotide

• Length: 183 bp

>T110860 NZ_CP031968:1265565-1265747 [Chromobacterium rhizoryzae]
GTGACCAGCAAAGAAGTCATCAGCATGATAGAGGCCGACGGCTGGTATCTGGTTGCCGCCAAGGGAAGCCATCAACAGTT
CAAACACCCGATCAAGACCGGCCGGGTGACGGTGCCTCACCCCAAGAAGGACATACCGATAGGCACACTGAACAGCATCA
AGAAACAAGCGGGTCTCAAGTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14891.91 Da
• Isoelectric Point: 4.6312

>AT110860 WP_107731681.1 NZ_CP031968:1265757-1266167 [Chromobacterium rhizoryzae]
MYYPIAVEPGDDQHAYGVIVPDLPGCFSAGDTLDEAIRNAREAIELHLEGLVEDLDVIPLASSAQAHVGKPEFAGHLWAL
VDVDITRYLGKATKINVTLPANLLHRIDEYVASHPEYDSRSGFLAKTALEKLLCRP

Nucleotide

• Length: 411 bp

>AT110860 NZ_CP031968:1265757-1266167 [Chromobacterium rhizoryzae]
ATGTACTACCCGATTGCAGTTGAACCCGGTGATGACCAACATGCCTATGGCGTCATCGTGCCGGATCTACCCGGCTGCTT
TTCCGCCGGGGACACTCTGGATGAGGCCATCCGAAATGCCCGCGAAGCCATTGAGCTACATCTGGAAGGGCTGGTGGAAG
ACCTGGACGTTATCCCTCTGGCCAGCAGTGCGCAGGCTCATGTCGGTAAACCCGAGTTTGCCGGCCATCTCTGGGCGCTG
GTGGATGTGGACATCACTCGCTATCTGGGTAAAGCGACCAAGATCAATGTCACGTTGCCGGCCAACCTTCTGCACCGTAT
CGATGAATATGTCGCTTCCCACCCGGAATATGATAGCCGCAGCGGTTTCCTGGCCAAGACCGCGCTAGAAAAGCTGTTGT
GTCGGCCGTAA

Structures

Toxin

• AlphaFold DB: A0A0J6MTI0