Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 3529558..3530134 Replicon chromosome
Accession NZ_CP031941
Organism Nostoc sphaeroides strain Kutzing En

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag D1367_RS15455 Protein ID WP_118167234.1
Coordinates 3529775..3530134 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag D1367_RS15450 Protein ID WP_118167233.1
Coordinates 3529558..3529788 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1367_RS15435 3526672..3527772 + 1101 WP_118167230.1 ATP-binding protein -
D1367_RS15440 3528182..3528451 + 270 WP_118167231.1 YciI family protein -
D1367_RS15445 3528570..3529364 + 795 WP_118167232.1 Tab2/Atab2 family RNA-binding protein -
D1367_RS15450 3529558..3529788 + 231 WP_118167233.1 CopG family transcriptional regulator Antitoxin
D1367_RS15455 3529775..3530134 + 360 WP_118167234.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
D1367_RS15460 3530164..3530424 + 261 WP_181984847.1 hypothetical protein -
D1367_RS15465 3530421..3531743 - 1323 WP_118167235.1 DNA (cytosine-5-)-methyltransferase -
D1367_RS15475 3532163..3533245 - 1083 WP_118167236.1 photosystem II q(b) protein -
D1367_RS15480 3533493..3533945 - 453 WP_118167237.1 Hsp20/alpha crystallin family protein -
D1367_RS15490 3534705..3535100 + 396 WP_118167239.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13261.44 Da        Isoelectric Point: 8.5043

>T110851 WP_118167234.1 NZ_CP031941:3529775-3530134 [Nostoc sphaeroides]
MPGNNLTYRRGEIRWVNLDPTVGAEAKKIRACLIVQNDIMNQCGLLTIVMPFRPGSKQAPYVVNVKATPNNGLDQDRFID
VGQIRAVDHSRILGLVGVLESEYWELIRTALNVVLGFVV

Download         Length: 360 bp

>T110851 NZ_CP031941:3529775-3530134 [Nostoc sphaeroides]
ATGCCAGGGAATAATTTAACTTATCGGCGAGGAGAAATACGTTGGGTTAATCTTGATCCAACAGTGGGGGCTGAAGCAAA
AAAAATCCGCGCTTGTTTGATTGTGCAAAATGACATCATGAATCAGTGTGGGTTGCTGACAATTGTTATGCCATTTCGAC
CTGGAAGTAAACAAGCCCCCTACGTTGTGAATGTCAAAGCAACACCAAATAATGGACTAGACCAAGACCGTTTTATTGAT
GTTGGGCAAATTCGTGCTGTTGACCATAGTCGTATTTTGGGTTTGGTGGGTGTGCTGGAGTCAGAATACTGGGAACTTAT
TCGTACAGCTTTAAATGTAGTTCTGGGATTTGTGGTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8563.62 Da        Isoelectric Point: 4.1677

>AT110851 WP_118167233.1 NZ_CP031941:3529558-3529788 [Nostoc sphaeroides]
MLKVTITLEEDILRFVDQYAQGNRSAYINTLLAEHRRQILAAEMIAALKQDAEDPEYQVEIAAWDSVAGDGINARE

Download         Length: 231 bp

>AT110851 NZ_CP031941:3529558-3529788 [Nostoc sphaeroides]
ATGCTCAAAGTCACAATTACCTTAGAAGAAGACATTCTGCGATTTGTAGATCAGTATGCACAGGGAAATCGTAGTGCATA
CATTAATACACTGCTGGCAGAACACCGCCGCCAAATTTTGGCAGCAGAAATGATTGCAGCCCTCAAGCAGGATGCCGAAG
ATCCAGAATATCAAGTTGAAATTGCTGCCTGGGATAGCGTTGCTGGAGATGGCATAAATGCCAGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References