Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 3352763..3353322 Replicon chromosome
Accession NZ_CP031941
Organism Nostoc sphaeroides strain Kutzing En

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1367_RS14725 Protein ID WP_118167104.1
Coordinates 3352984..3353322 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1367_RS14720 Protein ID WP_118167103.1
Coordinates 3352763..3352987 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1367_RS14715 3349131..3352727 + 3597 WP_118167102.1 transcription-repair coupling factor -
D1367_RS14720 3352763..3352987 + 225 WP_118167103.1 DUF433 domain-containing protein Antitoxin
D1367_RS14725 3352984..3353322 + 339 WP_118167104.1 DUF5615 family PIN-like protein Toxin
D1367_RS14730 3353336..3353587 - 252 WP_147337370.1 hypothetical protein -
D1367_RS14740 3353801..3354304 - 504 WP_118167106.1 DUF29 domain-containing protein -
D1367_RS14745 3354500..3354763 + 264 WP_118167107.1 hypothetical protein -
D1367_RS30855 3354747..3354896 + 150 WP_181984841.1 hypothetical protein -
D1367_RS14750 3355022..3355453 - 432 WP_118167108.1 NUDIX domain-containing protein -
D1367_RS14755 3355462..3355914 - 453 WP_100898442.1 DUF3531 family protein -
D1367_RS14760 3356034..3356993 - 960 WP_118167109.1 tetratricopeptide repeat protein -
D1367_RS14765 3357390..3358064 + 675 WP_118167110.1 energy-coupling factor ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12130.97 Da        Isoelectric Point: 4.0808

>T110850 WP_118167104.1 NZ_CP031941:3352984-3353322 [Nostoc sphaeroides]
MTIWVDAHLSPAIATWISNTFGITALALRDVGLRDAEDLQIFEAAKAQGVILITKDSDFVDLVVRLGSPPQIIWLTCGNT
SNARLQEILSATLLEALELLRTGEVLVEISGD

Download         Length: 339 bp

>T110850 NZ_CP031941:3352984-3353322 [Nostoc sphaeroides]
ATGACAATCTGGGTAGATGCACATTTATCCCCTGCGATCGCAACTTGGATCAGCAACACTTTTGGTATAACAGCTTTAGC
TTTACGTGATGTTGGTCTGAGAGATGCTGAAGACCTTCAGATTTTTGAGGCAGCAAAAGCTCAAGGAGTTATCTTGATAA
CCAAGGATAGCGACTTTGTTGACTTGGTTGTTCGTCTTGGATCACCACCACAAATTATCTGGTTAACGTGCGGAAACACA
TCAAATGCTCGGTTGCAAGAGATTTTGAGTGCTACTTTGCTAGAAGCATTAGAGCTTTTGCGAACAGGTGAAGTGTTAGT
CGAAATTAGCGGAGATTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8161.61 Da        Isoelectric Point: 6.9478

>AT110850 WP_118167103.1 NZ_CP031941:3352763-3352987 [Nostoc sphaeroides]
MSELLKRITVNPKQCGGRPCIRGMRIRVSDVLDLFAAGLSAEQILEEMPDLEADDLKAALIYASRKLNHPVLVA

Download         Length: 225 bp

>AT110850 NZ_CP031941:3352763-3352987 [Nostoc sphaeroides]
ATGTCAGAATTACTTAAAAGAATTACAGTTAATCCCAAACAATGTGGTGGTCGTCCATGCATTCGAGGCATGAGAATTCG
GGTATCAGATGTACTGGACTTGTTTGCTGCTGGACTTAGTGCAGAACAAATTTTAGAAGAAATGCCTGATCTTGAAGCCG
ACGATCTCAAAGCAGCACTAATATATGCTTCGCGGAAGCTTAATCATCCAGTCTTAGTAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References