Detailed information of TA system TA110847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 1003001..1003641
• Replicon: chromosome
• Accession: NZ_CP031941
• Organism: Nostoc sphaeroides strain Kutzing En

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1367_RS04660
• Protein ID: WP_118163665.1
• Coordinates: 1003243..1003641 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D1367_RS04655
• Protein ID: WP_118163661.1
• Coordinates: 1003001..1003246 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1367_RS04625	998651..998953	-	303	WP_181985070.1	hypothetical protein	-
D1367_RS04630	999193..1000662	-	1470	WP_118163648.1	site-specific integrase	-
D1367_RS04635	1000779..1001879	+	1101	Protein_899	nickel-dependent hydrogenase large subunit	-
D1367_RS04640	1001967..1002176	+	210	WP_118163653.1	hypothetical protein	-
D1367_RS04645	1002173..1002589	+	417	WP_118163656.1	HNH endonuclease	-
D1367_RS04650	1002650..1002860	-	211	Protein_902	type II toxin-antitoxin system HicB family antitoxin	-
D1367_RS04655	1003001..1003246	+	246	WP_118163661.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1367_RS04660	1003243..1003641	+	399	WP_118163665.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1367_RS04665	1003742..1004479	-	738	WP_118163669.1	SDR family oxidoreductase	-
D1367_RS04670	1004582..1004914	+	333	WP_118163673.1	winged helix-turn-helix transcriptional regulator	-
D1367_RS04675	1005227..1005649	+	423	WP_118163676.1	hypothetical protein	-
D1367_RS04680	1005718..1006131	-	414	WP_118163680.1	PIN domain-containing protein	-
D1367_RS04685	1006128..1006403	-	276	WP_118163684.1	DUF2281 domain-containing protein	-
D1367_RS04690	1006491..1006961	+	471	WP_118163687.1	hydrogenase maturation protease	-
D1367_RS04695	1007008..1007382	-	375	WP_118163691.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	955076..1041522	86446

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-41)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14969.39 Da
• Isoelectric Point: 4.6485

>T110847 WP_118163665.1 NZ_CP031941:1003243-1003641 [Nostoc sphaeroides]
VKLLLDTQCWLWWFTQPELLNEAAIAHIADETNELWLSVASIWEIGIKVAIGKLPLPDPLDSYISSRMTVLAMRSLEITA
SHALQAAALPLHHRDPFDRMFIAQAQIEEMTLVSADSMFYKYDISLLWAAKS

Nucleotide

• Length: 399 bp

>T110847 NZ_CP031941:1003243-1003641 [Nostoc sphaeroides]
GTGAAACTTTTGCTAGATACGCAGTGTTGGTTATGGTGGTTTACCCAACCAGAGCTTTTGAATGAAGCAGCGATCGCCCA
TATTGCCGATGAAACGAATGAATTGTGGCTCTCAGTTGCCAGTATTTGGGAAATAGGGATAAAAGTTGCGATCGGCAAGT
TACCATTGCCAGACCCCTTAGACAGTTATATTTCTAGTCGGATGACGGTGTTGGCAATGCGCTCGCTAGAAATTACAGCT
TCTCATGCTTTACAAGCGGCTGCTTTACCTTTGCACCACCGAGATCCTTTTGACAGAATGTTCATTGCACAGGCTCAGAT
AGAAGAAATGACGCTTGTGAGTGCCGATTCGATGTTTTATAAGTACGACATTTCCCTACTTTGGGCAGCCAAATCTTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8912.09 Da
• Isoelectric Point: 4.7616

>AT110847 WP_118163661.1 NZ_CP031941:1003001-1003246 [Nostoc sphaeroides]
METVNIHQAKTNLSKLLSRVELGEEIIISNRGIPVAKLVPFHNSSNRLNSLGQDKGRFVVPDDFNAPLPEEILAAFEGGE
E

Nucleotide

• Length: 246 bp

>AT110847 NZ_CP031941:1003001-1003246 [Nostoc sphaeroides]
ATGGAAACTGTAAATATTCATCAAGCTAAAACGAATCTCTCAAAGCTGTTGTCGCGCGTAGAACTTGGCGAAGAAATCAT
TATTTCCAACCGAGGTATTCCTGTTGCCAAGTTGGTTCCGTTTCACAACTCATCAAATCGACTCAATAGTTTAGGGCAGG
ATAAAGGGCGTTTTGTAGTACCAGATGATTTCAATGCCCCTTTACCAGAAGAAATTTTGGCAGCATTTGAGGGTGGTGAG
GAGTGA