Detailed information of TA system TA110846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 535478..536014
• Replicon: chromosome
• Accession: NZ_CP031941
• Organism: Nostoc sphaeroides strain Kutzing En

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D1367_RS02540
• Protein ID: WP_118162476.1
• Coordinates: 535715..536014 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: D1367_RS02535
• Protein ID: WP_118162474.1
• Coordinates: 535478..535711 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1367_RS02520	532441..532869	+	429	WP_118162466.1	peptidoglycan-binding protein	-
D1367_RS02525	532932..534596	-	1665	WP_118162468.1	hypothetical protein	-
D1367_RS02530	534989..535258	+	270	WP_118162471.1	hypothetical protein	-
D1367_RS02535	535478..535711	+	234	WP_118162474.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
D1367_RS02540	535715..536014	+	300	WP_118162476.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1367_RS02545	536081..536353	+	273	WP_118162479.1	hypothetical protein	-
D1367_RS02550	536350..536715	+	366	WP_118162481.1	clan AA aspartic protease	-
D1367_RS02555	536839..537816	-	978	WP_118162484.1	Bpu10I family restriction endonuclease	-
D1367_RS02560	537789..539030	-	1242	WP_118162487.1	DNA cytosine methyltransferase	-
D1367_RS02565	539300..539569	+	270	WP_118162489.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• Antitoxin ParD (1-75)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11910.38 Da
• Isoelectric Point: 6.6359

>T110846 WP_118162476.1 NZ_CP031941:535715-536014 [Nostoc sphaeroides]
MSAFRLTELATQDLLSIGRYTQKTWGTEQRNRYLAILDDCFHVLAREPHRGRTCDDIRSGYRKYHIGRHLIFYQETNETI
DIIRILHDRMDVESYFNED

Nucleotide

• Length: 300 bp

>T110846 NZ_CP031941:535715-536014 [Nostoc sphaeroides]
ATGTCAGCATTTCGCCTTACTGAATTAGCCACTCAAGACTTGCTATCAATCGGTCGCTACACCCAAAAAACATGGGGAAC
TGAGCAGAGAAACCGTTATCTTGCTATCTTGGACGATTGCTTTCATGTCTTGGCACGAGAGCCACACAGAGGACGTACTT
GTGATGATATTCGCTCAGGATATCGCAAGTACCACATCGGACGACATTTGATCTTTTATCAGGAAACTAATGAAACTATC
GATATTATTCGTATTTTGCATGATCGTATGGATGTGGAGTCTTATTTCAACGAAGACTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8428.39 Da
• Isoelectric Point: 4.4423

>AT110846 WP_118162474.1 NZ_CP031941:535478-535711 [Nostoc sphaeroides]
MQKNTSVTLGEHFEAFIANQVESGRFASASEAIRAGLRLLEEREIKLAALQRALTDGENSGFAEYSLSGLLAELDRE

Nucleotide

• Length: 234 bp

>AT110846 NZ_CP031941:535478-535711 [Nostoc sphaeroides]
ATGCAAAAAAATACAAGTGTTACCTTGGGTGAGCATTTTGAAGCGTTTATCGCCAATCAAGTTGAAAGCGGTCGTTTTGC
CAGCGCCAGTGAAGCGATTCGAGCAGGACTGCGCCTTTTAGAAGAGCGAGAAATAAAACTTGCCGCTTTGCAACGAGCAT
TGACAGACGGGGAAAATAGCGGATTTGCTGAGTATTCTCTCTCAGGATTGCTTGCAGAACTTGACCGTGAATAG