Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 23937..24847 Replicon plasmid unnamed1
Accession NZ_CP031935
Organism Klebsiella pneumoniae strain GZ-1

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag D1368_RS27145 Protein ID WP_004026354.1
Coordinates 23937..24407 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag D1368_RS27150 Protein ID WP_004026357.1
Coordinates 24404..24847 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1368_RS27105 19253..19567 + 315 WP_011251273.1 hypothetical protein -
D1368_RS27110 19576..20086 + 511 Protein_20 hypothetical protein -
D1368_RS27115 20076..20516 + 441 WP_011251275.1 hypothetical protein -
D1368_RS27120 20941..21897 - 957 WP_011251280.1 DsbA family protein -
D1368_RS27125 21957..22298 - 342 WP_011251281.1 hypothetical protein -
D1368_RS27130 22312..22623 - 312 WP_011251282.1 hypothetical protein -
D1368_RS27135 22640..23074 - 435 Protein_25 thioredoxin fold domain-containing protein -
D1368_RS27140 23091..23788 - 698 Protein_26 IS1 family transposase -
D1368_RS27145 23937..24407 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
D1368_RS27150 24404..24847 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
D1368_RS27155 24948..25451 - 504 Protein_29 DUF4113 domain-containing protein -
D1368_RS27160 25657..26637 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
D1368_RS27165 26703..28010 + 1308 Protein_31 FepA family TonB-dependent siderophore receptor -
D1368_RS27170 28072..28293 + 222 WP_004213615.1 hypothetical protein -
D1368_RS27175 28436..29338 - 903 WP_004213613.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..198126 198126
- inside IScluster/Tn - iroN / rmpA 17656..37632 19976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T110833 WP_004026354.1 NZ_CP031935:c24407-23937 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T110833 NZ_CP031935:c24407-23937 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT110833 WP_004026357.1 NZ_CP031935:c24847-24404 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT110833 NZ_CP031935:c24847-24404 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References