Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3515344..3515860 Replicon chromosome
Accession NZ_CP031934
Organism Klebsiella pneumoniae strain GZ-1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag D1368_RS17320 Protein ID WP_002886902.1
Coordinates 3515576..3515860 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag D1368_RS17315 Protein ID WP_002886901.1
Coordinates 3515344..3515586 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1368_RS17300 3511373..3512113 + 741 WP_002886899.1 KDGP aldolase family protein -
D1368_RS17305 3512179..3513333 + 1155 WP_002886900.1 lactonase family protein -
D1368_RS17310 3513356..3515266 + 1911 WP_004152270.1 BglG family transcription antiterminator -
D1368_RS17315 3515344..3515586 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D1368_RS17320 3515576..3515860 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1368_RS17325 3515864..3516328 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
D1368_RS17330 3516569..3518707 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
D1368_RS17335 3519064..3519807 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
D1368_RS17340 3519810..3519983 - 174 WP_002886906.1 hypothetical protein -
D1368_RS17345 3520068..3520376 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T110830 WP_002886902.1 NZ_CP031934:3515576-3515860 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T110830 NZ_CP031934:3515576-3515860 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT110830 WP_002886901.1 NZ_CP031934:3515344-3515586 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT110830 NZ_CP031934:3515344-3515586 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References