Detailed information of TA system TA110805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2879378..2880016
• Replicon: chromosome
• Accession: NZ_CP031922
• Organism: Escherichia coli O26:H11 strain FWSEC0001

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: B9S25_RS14910
• Protein ID: WP_000813794.1
• Coordinates: 2879840..2880016 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: B9S25_RS14905
• Protein ID: WP_001270286.1
• Coordinates: 2879378..2879794 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9S25_RS14885	2874531..2875472	-	942	WP_001251332.1	ABC transporter permease	-
B9S25_RS14890	2875473..2876486	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
B9S25_RS14895	2876504..2877649	-	1146	WP_000047456.1	ABC transporter substrate-binding protein	-
B9S25_RS14900	2877894..2879299	-	1406	Protein_2858	PLP-dependent aminotransferase family protein	-
B9S25_RS14905	2879378..2879794	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
B9S25_RS14910	2879840..2880016	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
B9S25_RS14915	2880238..2880468	+	231	WP_000494244.1	YncJ family protein	-
B9S25_RS14920	2880560..2882521	-	1962	WP_044862087.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
B9S25_RS14925	2882594..2883130	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
B9S25_RS14930	2883183..2884397	+	1215	WP_001307190.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2884437..2885585	1148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T110805 WP_000813794.1 NZ_CP031922:c2880016-2879840 [Escherichia coli O26:H11]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T110805 NZ_CP031922:c2880016-2879840 [Escherichia coli O26:H11]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT110805 WP_001270286.1 NZ_CP031922:c2879794-2879378 [Escherichia coli O26:H11]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT110805 NZ_CP031922:c2879794-2879378 [Escherichia coli O26:H11]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• PDB: 6HPB