Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2706830..2707356 | Replicon | chromosome |
| Accession | NZ_CP031922 | ||
| Organism | Escherichia coli O26:H11 strain FWSEC0001 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | B9S25_RS14075 | Protein ID | WP_000323025.1 |
| Coordinates | 2707069..2707356 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | B9S25_RS14070 | Protein ID | WP_000534858.1 |
| Coordinates | 2706830..2707069 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B9S25_RS14035 | 2702016..2702243 | + | 228 | WP_000476993.1 | transcriptional regulator | - |
| B9S25_RS14040 | 2702227..2702748 | + | 522 | WP_000705349.1 | hypothetical protein | - |
| B9S25_RS14045 | 2702729..2703694 | + | 966 | WP_000054507.1 | hypothetical protein | - |
| B9S25_RS14050 | 2703735..2704154 | + | 420 | WP_001151195.1 | DUF977 family protein | - |
| B9S25_RS14055 | 2704188..2705528 | + | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| B9S25_RS14060 | 2705965..2706297 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| B9S25_RS14065 | 2706500..2706805 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| B9S25_RS14070 | 2706830..2707069 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| B9S25_RS14075 | 2707069..2707356 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| B9S25_RS14080 | 2707428..2707583 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| B9S25_RS14085 | 2707800..2708051 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| B9S25_RS14090 | 2708118..2708396 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| B9S25_RS14095 | 2708398..2709447 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| B9S25_RS14100 | 2709461..2710214 | + | 754 | Protein_2699 | antitermination protein | - |
| B9S25_RS14105 | 2710492..2710581 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| B9S25_RS14110 | 2710636..2710848 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| B9S25_RS14115 | 2711149..2711364 | + | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| B9S25_RS30645 | 2711728..2711898 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| B9S25_RS14120 | 2712118..2712333 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2692702..2754226 | 61524 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T110803 WP_000323025.1 NZ_CP031922:2707069-2707356 [Escherichia coli O26:H11]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T110803 NZ_CP031922:2707069-2707356 [Escherichia coli O26:H11]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT110803 WP_000534858.1 NZ_CP031922:2706830-2707069 [Escherichia coli O26:H11]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT110803 NZ_CP031922:2706830-2707069 [Escherichia coli O26:H11]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|