Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2349406..2349877 | Replicon | chromosome |
| Accession | NZ_CP031922 | ||
| Organism | Escherichia coli O26:H11 strain FWSEC0001 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | B9S25_RS12030 | Protein ID | WP_001303511.1 |
| Coordinates | 2349406..2349684 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | B9S25_RS12035 | Protein ID | WP_001302048.1 |
| Coordinates | 2349686..2349877 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B9S25_RS12005 | 2345056..2347707 | - | 2652 | WP_000105101.1 | exodeoxyribonuclease VIII | - |
| B9S25_RS12010 | 2347806..2348081 | - | 276 | WP_001307773.1 | hypothetical protein | - |
| B9S25_RS12015 | 2348155..2348331 | - | 177 | WP_000245534.1 | hypothetical protein | - |
| B9S25_RS12020 | 2348325..2348546 | - | 222 | WP_000560218.1 | killing protein KilR | - |
| B9S25_RS12025 | 2348967..2349119 | - | 153 | WP_001427316.1 | DUF1391 family protein | - |
| B9S25_RS12030 | 2349406..2349684 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| B9S25_RS12035 | 2349686..2349877 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| B9S25_RS12040 | 2349898..2350269 | - | 372 | WP_001169687.1 | hypothetical protein | - |
| B9S25_RS12045 | 2350367..2350669 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| B9S25_RS12050 | 2350666..2351091 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| B9S25_RS12055 | 2351114..2352076 | + | 963 | WP_001444941.1 | helix-turn-helix domain-containing protein | - |
| B9S25_RS12060 | 2352083..2352824 | + | 742 | Protein_2306 | ATP-binding protein | - |
| B9S25_RS12065 | 2352850..2353611 | + | 762 | WP_000450872.1 | DUF1627 domain-containing protein | - |
| B9S25_RS12070 | 2353644..2353925 | + | 282 | WP_000603384.1 | DNA-binding protein | - |
| B9S25_RS12075 | 2353922..2354149 | + | 228 | WP_000699809.1 | hypothetical protein | - |
| B9S25_RS12080 | 2354142..2354453 | + | 312 | WP_001289673.1 | hypothetical protein | - |
| B9S25_RS12085 | 2354581..2354799 | + | 219 | WP_000683609.1 | DUF4014 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2342392..2356662 | 14270 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T110802 WP_001303511.1 NZ_CP031922:c2349684-2349406 [Escherichia coli O26:H11]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T110802 NZ_CP031922:c2349684-2349406 [Escherichia coli O26:H11]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT110802 WP_001302048.1 NZ_CP031922:c2349877-2349686 [Escherichia coli O26:H11]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT110802 NZ_CP031922:c2349877-2349686 [Escherichia coli O26:H11]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|