Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2046261..2047096 Replicon chromosome
Accession NZ_CP031922
Organism Escherichia coli O26:H11 strain FWSEC0001

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag B9S25_RS10340 Protein ID WP_000854757.1
Coordinates 2046261..2046638 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag B9S25_RS10345 Protein ID WP_001295723.1
Coordinates 2046728..2047096 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9S25_RS10300 2041781..2042254 + 474 WP_001105384.1 DNA gyrase inhibitor SbmC -
B9S25_RS10305 2042452..2043510 + 1059 WP_001200883.1 FUSC family protein -
B9S25_RS10310 2043682..2044011 + 330 WP_000450409.1 DUF496 family protein -
B9S25_RS10315 2044112..2044294 - 183 WP_024167529.1 ethanolamine utilization protein -
B9S25_RS10325 2044748..2045776 - 1029 Protein_1988 IS110 family transposase -
B9S25_RS10330 2045935..2046048 - 114 WP_001161660.1 DUF957 domain-containing protein -
B9S25_RS10335 2046061..2046264 - 204 WP_000761705.1 hypothetical protein -
B9S25_RS10340 2046261..2046638 - 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
B9S25_RS10345 2046728..2047096 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
B9S25_RS10350 2047259..2047480 - 222 WP_000692323.1 DUF987 domain-containing protein -
B9S25_RS10355 2047549..2048025 - 477 WP_001186725.1 RadC family protein -
B9S25_RS10360 2048041..2048526 - 486 WP_000849582.1 antirestriction protein -
B9S25_RS10365 2048581..2049399 - 819 WP_001234620.1 DUF945 domain-containing protein -
B9S25_RS10375 2049499..2049732 - 234 WP_001119729.1 DUF905 family protein -
B9S25_RS10380 2049811..2050152 - 342 WP_072097794.1 hypothetical protein -
B9S25_RS10385 2050241..2050645 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
B9S25_RS10390 2050642..2050989 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T110789 WP_000854757.1 NZ_CP031922:c2046638-2046261 [Escherichia coli O26:H11]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T110789 NZ_CP031922:c2046638-2046261 [Escherichia coli O26:H11]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT110789 WP_001295723.1 NZ_CP031922:c2047096-2046728 [Escherichia coli O26:H11]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT110789 NZ_CP031922:c2047096-2046728 [Escherichia coli O26:H11]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References