Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3694550..3695385 | Replicon | chromosome |
| Accession | NZ_CP031919 | ||
| Organism | Escherichia coli O145:NM strain FWSEC0002 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2A3UQ69 |
| Locus tag | CCU01_RS19340 | Protein ID | WP_000854714.1 |
| Coordinates | 3694550..3694927 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A2A3UQI5 |
| Locus tag | CCU01_RS19345 | Protein ID | WP_001285574.1 |
| Coordinates | 3695017..3695385 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCU01_RS19300 | 3689874..3690578 | + | 705 | WP_001241688.1 | leucyl/phenylalanyl-tRNA--protein transferase | - |
| CCU01_RS19305 | 3690863..3691081 | + | 219 | WP_001040187.1 | translation initiation factor IF-1 | - |
| CCU01_RS19315 | 3691572..3691853 | - | 282 | Protein_3683 | DUF4942 domain-containing protein | - |
| CCU01_RS19320 | 3692135..3693139 | - | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| CCU01_RS19325 | 3693211..3693771 | - | 561 | Protein_3685 | DUF4942 domain-containing protein | - |
| CCU01_RS19330 | 3693856..3694053 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| CCU01_RS19335 | 3694065..3694553 | - | 489 | WP_000761724.1 | hypothetical protein | - |
| CCU01_RS19340 | 3694550..3694927 | - | 378 | WP_000854714.1 | TA system toxin CbtA family protein | Toxin |
| CCU01_RS19345 | 3695017..3695385 | - | 369 | WP_001285574.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| CCU01_RS19350 | 3695465..3695686 | - | 222 | WP_000692328.1 | DUF987 domain-containing protein | - |
| CCU01_RS19355 | 3695749..3696225 | - | 477 | WP_001186726.1 | RadC family protein | - |
| CCU01_RS19360 | 3696241..3696714 | - | 474 | WP_001456342.1 | antirestriction protein | - |
| CCU01_RS19365 | 3696808..3697053 | - | 246 | WP_000680582.1 | hypothetical protein | - |
| CCU01_RS19370 | 3697053..3697871 | - | 819 | WP_001234742.1 | DUF945 domain-containing protein | - |
| CCU01_RS19380 | 3697961..3698184 | - | 224 | Protein_3695 | DUF905 domain-containing protein | - |
| CCU01_RS19385 | 3698282..3698695 | - | 414 | WP_000789534.1 | hypothetical protein | - |
| CCU01_RS19390 | 3698965..3699504 | - | 540 | WP_001104024.1 | DUF4339 domain-containing protein | - |
| CCU01_RS29815 | 3699630..3700087 | - | 458 | Protein_3698 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3692135..3693139 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14216.31 Da Isoelectric Point: 7.8046
>T110776 WP_000854714.1 NZ_CP031919:c3694927-3694550 [Escherichia coli O145:NM]
MKTLPDTHVREASRCPSPVIIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVDNITLGKHPEAKR
MKTLPDTHVREASRCPSPVIIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVDNITLGKHPEAKR
Download Length: 378 bp
>T110776 NZ_CP031919:c3694927-3694550 [Escherichia coli O145:NM]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGATTCTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAGATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGATTCTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAGATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13578.33 Da Isoelectric Point: 6.3152
>AT110776 WP_001285574.1 NZ_CP031919:c3695385-3695017 [Escherichia coli O145:NM]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT110776 NZ_CP031919:c3695385-3695017 [Escherichia coli O145:NM]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A3UQ69 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A3UQI5 |