Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4507962..4508616 Replicon chromosome
Accession NZ_CP031916
Organism Escherichia coli O45:H2 strain FWSEC0003

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag CCU02_RS23220 Protein ID WP_000244772.1
Coordinates 4507962..4508369 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CCU02_RS23225 Protein ID WP_000354046.1
Coordinates 4508350..4508616 (-) Length 89 a.a.

Genomic Context

CCU02_RS23215CCU02_RS23230CCU02_RS23240CCU02_RS23200CCU02_RS23205CCU02_RS23210CCU02_RS23220CCU02_RS23225CCU02_RS23245CCU02_RS23250
Location: 4507401..4507922 (522 bp)
Type: Others
Protein ID: WP_001055874.1
Location: 4508859..4509839 (981 bp)
Type: Others
Protein ID: WP_000886062.1
Location: 4510092..4511072 (981 bp)
Type: Others
Protein ID: WP_000399680.1
Location: 4503919..4505652 (1734 bp)
Type: Others
Protein ID: WP_000813223.1
Location: 4505658..4506368 (711 bp)
Type: Others
Protein ID: WP_000715208.1
Location: 4506393..4507289 (897 bp)
Type: Others
Protein ID: WP_000806638.1
Location: 4507962..4508369 (408 bp)
Type: Toxin
Protein ID: WP_000244772.1
Location: 4508350..4508616 (267 bp)
Type: Antitoxin
Protein ID: WP_000354046.1
Location: 4511195..4511854 (660 bp)
Type: Others
Protein ID: WP_000250274.1
Location: 4512018..4512329 (312 bp)
Type: Others
Protein ID: WP_001182947.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CCU02_RS232004503919..4505652-1734WP_000813223.1single-stranded-DNA-specific exonuclease RecJ-
CCU02_RS232054505658..4506368-711WP_000715208.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
CCU02_RS232104506393..4507289-897WP_000806638.1site-specific tyrosine recombinase XerD-
CCU02_RS232154507401..4507922+522WP_001055874.1flavodoxin FldB-
CCU02_RS232204507962..4508369-408WP_000244772.1protein YgfXToxin
CCU02_RS232254508350..4508616-267WP_000354046.1FAD assembly factor SdhEAntitoxin
CCU02_RS232304508859..4509839+981WP_000886062.1tRNA-modifying protein YgfZ-
CCU02_RS232404510092..4511072+981WP_000399680.1IS110-like element IS621 family transposase-
CCU02_RS232454511195..4511854-660WP_000250274.1hemolysin III family protein-
CCU02_RS232504512018..4512329-312WP_001182947.1N(4)-acetylcytidine aminohydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--4510092..4511072980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T110749 WP_000244772.1 NZ_CP031916:c4508369-4507962 [Escherichia coli O45:H2]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T110749 NZ_CP031916:c4508369-4507962 [Escherichia coli O45:H2]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT110749 WP_000354046.1 NZ_CP031916:c4508616-4508350 [Escherichia coli O45:H2]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT110749 NZ_CP031916:c4508616-4508350 [Escherichia coli O45:H2]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0XYB4

Antitoxin

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Source
ID
Structure
PDB6B58
PDB1X6I
PDB1X6J
PDB6C12
AlphaFold DBA0A7U9QD57

References