Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1982942..1983420 Replicon chromosome
Accession NZ_CP031916
Organism Escherichia coli O45:H2 strain FWSEC0003

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag CCU02_RS09605 Protein ID WP_001303876.1
Coordinates 1982942..1983229 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag CCU02_RS09610 Protein ID WP_000536233.1
Coordinates 1983229..1983420 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCU02_RS09570 1978092..1980563 - 2472 WP_000034468.1 exonuclease -
CCU02_RS09575 1980657..1980848 - 192 WP_001098307.1 DUF1482 family protein -
CCU02_RS09580 1980845..1981033 - 189 WP_000413705.1 cell division inhibition protein DicB -
CCU02_RS09590 1981607..1981792 + 186 WP_001133046.1 hypothetical protein -
CCU02_RS09595 1981979..1982368 - 390 WP_000394511.1 hypothetical protein -
CCU02_RS09600 1982510..1982665 - 156 WP_000379575.1 DUF1391 family protein -
CCU02_RS09605 1982942..1983229 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCU02_RS09610 1983229..1983420 - 192 WP_000536233.1 hypothetical protein Antitoxin
CCU02_RS09615 1983448..1983849 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
CCU02_RS09620 1983958..1984230 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
CCU02_RS09625 1984214..1984639 + 426 WP_000693855.1 Rha family transcriptional regulator -
CCU02_RS09630 1984846..1985301 - 456 WP_000273724.1 hypothetical protein -
CCU02_RS09635 1985380..1986495 + 1116 WP_001205820.1 hypothetical protein -
CCU02_RS09640 1986502..1987188 + 687 WP_000788749.1 ATP-binding protein -
CCU02_RS09645 1987270..1988040 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T110730 WP_001303876.1 NZ_CP031916:c1983229-1982942 [Escherichia coli O45:H2]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T110730 NZ_CP031916:c1983229-1982942 [Escherichia coli O45:H2]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT110730 WP_000536233.1 NZ_CP031916:c1983420-1983229 [Escherichia coli O45:H2]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT110730 NZ_CP031916:c1983420-1983229 [Escherichia coli O45:H2]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References