Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 488759..489557 | Replicon | chromosome |
| Accession | NZ_CP031916 | ||
| Organism | Escherichia coli O45:H2 strain FWSEC0003 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0F3UPG9 |
| Locus tag | CCU02_RS02270 | Protein ID | WP_000854698.1 |
| Coordinates | 488759..489136 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0F3T7G0 |
| Locus tag | CCU02_RS02275 | Protein ID | WP_000017094.1 |
| Coordinates | 489183..489557 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCU02_RS02250 | 484851..486389 | - | 1539 | WP_001187182.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
| CCU02_RS02255 | 487138..487980 | - | 843 | WP_001280439.1 | DUF4942 domain-containing protein | - |
| CCU02_RS02260 | 488065..488262 | - | 198 | WP_000839251.1 | DUF957 domain-containing protein | - |
| CCU02_RS02265 | 488274..488762 | - | 489 | WP_032360531.1 | hypothetical protein | - |
| CCU02_RS02270 | 488759..489136 | - | 378 | WP_000854698.1 | TA system toxin CbtA family protein | Toxin |
| CCU02_RS02275 | 489183..489557 | - | 375 | WP_000017094.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CCU02_RS02280 | 489632..489853 | - | 222 | WP_001220316.1 | DUF987 domain-containing protein | - |
| CCU02_RS02285 | 489922..490398 | - | 477 | WP_032313319.1 | RadC family protein | - |
| CCU02_RS02290 | 490414..490899 | - | 486 | WP_000213700.1 | antirestriction protein | - |
| CCU02_RS02295 | 490990..491430 | - | 441 | Protein_432 | DUF932 domain-containing protein | - |
| CCU02_RS02300 | 491549..493327 | - | 1779 | WP_001243195.1 | reverse transcriptase/maturase family protein | - |
| CCU02_RS02305 | 493837..494217 | - | 381 | Protein_434 | DUF932 domain-containing protein | - |
| CCU02_RS02315 | 494372..494530 | - | 159 | WP_001369071.1 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | efa1 / efa1 / efa1 / efa1 / efa1 / efa1 / efa1 / efa1 / efa1 / efa1 / nleE / nleB1 / espL2 | 477362..534465 | 57103 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13975.94 Da Isoelectric Point: 7.9087
>T110724 WP_000854698.1 NZ_CP031916:c489136-488759 [Escherichia coli O45:H2]
MKTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
MKTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
Download Length: 378 bp
>T110724 NZ_CP031916:c489136-488759 [Escherichia coli O45:H2]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGCACGGAGGCAAAACGATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGCACGGAGGCAAAACGATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13732.42 Da Isoelectric Point: 5.4488
>AT110724 WP_000017094.1 NZ_CP031916:c489557-489183 [Escherichia coli O45:H2]
VSGTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSGTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT110724 NZ_CP031916:c489557-489183 [Escherichia coli O45:H2]
GTGTCAGGCACACTCCATGAGACAAATTATCCCAACGACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAATTACATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGGCACACTCCATGAGACAAATTATCCCAACGACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAATTACATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F3UPG9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F3T7G0 |