Detailed information of TA system TA110660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 5005537..5006525
• Replicon: chromosome
• Accession: NZ_CP031910
• Organism: Escherichia coli O121:H19 strain FWSEC0006

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: B9X35_RS25515
• Protein ID: WP_014640052.1
• Coordinates: 5005537..5005923 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0A1AFM1
• Locus tag: B9X35_RS25520
• Protein ID: WP_000458583.1
• Coordinates: 5005953..5006525 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9X35_RS25470	5000543..5001367	+	825	WP_000081294.1	YfdQ family protein	-
B9X35_RS25475	5001495..5002031	+	537	WP_000008211.1	5'-deoxynucleotidase	-
B9X35_RS25480	5002022..5002372	+	351	WP_001242740.1	hypothetical protein	-
B9X35_RS25485	5002369..5002842	+	474	WP_000145671.1	class I SAM-dependent methyltransferase	-
B9X35_RS25490	5002989..5003456	+	468	WP_000829413.1	hypothetical protein	-
B9X35_RS25495	5003458..5003649	+	192	WP_001014294.1	hypothetical protein	-
B9X35_RS25500	5003652..5004386	+	735	WP_001094871.1	DUF551 domain-containing protein	-
B9X35_RS25505	5004386..5004958	+	573	WP_001061339.1	3'-5' exoribonuclease	-
B9X35_RS25510	5004995..5005276	+	282	WP_001093921.1	pyocin activator PrtN family protein	-
B9X35_RS28000	5005324..5005497	-	174	WP_000390069.1	hypothetical protein	-
B9X35_RS25515	5005537..5005923	-	387	WP_014640052.1	hypothetical protein	Toxin
B9X35_RS25520	5005953..5006525	-	573	WP_000458583.1	SocA family protein	Antitoxin
B9X35_RS25525	5006760..5006882	-	123	WP_001300034.1	hypothetical protein	-
B9X35_RS25530	5007245..5008231	-	987	WP_000912572.1	DUF2713 domain-containing protein	-
B9X35_RS25540	5008549..5009064	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
B9X35_RS25545	5009106..5009315	-	210	WP_001030593.1	CsbD family protein	-
B9X35_RS25550	5009431..5010756	-	1326	WP_001370252.1	MATE family efflux transporter DinF	-
B9X35_RS25555	5010829..5011437	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	4950801..5011437	60636

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T110660 WP_014640052.1 NZ_CP031910:c5005923-5005537 [Escherichia coli O121:H19]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T110660 NZ_CP031910:c5005923-5005537 [Escherichia coli O121:H19]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGGGTCCCCCACGATCCGTCTTGCGTCTTGAATTCCGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21956.30 Da
• Isoelectric Point: 6.0283

>AT110660 WP_000458583.1 NZ_CP031910:c5006525-5005953 [Escherichia coli O121:H19]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT110660 NZ_CP031910:c5006525-5005953 [Escherichia coli O121:H19]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0A1AFM1