Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3404701..3405179 Replicon chromosome
Accession NZ_CP031910
Organism Escherichia coli O121:H19 strain FWSEC0006

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag B9X35_RS17705 Protein ID WP_001303876.1
Coordinates 3404892..3405179 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag B9X35_RS17700 Protein ID WP_000536233.1
Coordinates 3404701..3404892 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9X35_RS17665 3400084..3400854 - 771 WP_000450862.1 DUF1627 domain-containing protein -
B9X35_RS17670 3400880..3401620 - 741 WP_000788752.1 ATP-binding protein -
B9X35_RS17675 3401617..3402741 - 1125 WP_072097015.1 DNA-binding protein -
B9X35_RS17680 3402820..3403275 + 456 WP_000273724.1 hypothetical protein -
B9X35_RS17685 3403482..3403907 - 426 WP_000693855.1 Rha family transcriptional regulator -
B9X35_RS17690 3403891..3404163 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
B9X35_RS17695 3404272..3404673 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
B9X35_RS17700 3404701..3404892 + 192 WP_000536233.1 hypothetical protein Antitoxin
B9X35_RS17705 3404892..3405179 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B9X35_RS17710 3405456..3405611 + 156 WP_000379575.1 DUF1391 family protein -
B9X35_RS17715 3405753..3406142 + 390 WP_000394511.1 hypothetical protein -
B9X35_RS17720 3406329..3406514 - 186 WP_001133046.1 hypothetical protein -
B9X35_RS17730 3407088..3407276 + 189 WP_000413705.1 cell division inhibition protein DicB -
B9X35_RS17735 3407273..3407464 + 192 WP_001098307.1 DUF1482 family protein -
B9X35_RS17740 3407558..3410029 + 2472 WP_000034468.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T110655 WP_001303876.1 NZ_CP031910:3404892-3405179 [Escherichia coli O121:H19]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T110655 NZ_CP031910:3404892-3405179 [Escherichia coli O121:H19]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT110655 WP_000536233.1 NZ_CP031910:3404701-3404892 [Escherichia coli O121:H19]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT110655 NZ_CP031910:3404701-3404892 [Escherichia coli O121:H19]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References