Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4748592..4749187 Replicon chromosome
Accession NZ_CP031908
Organism Escherichia coli O103:H2 strain FWSEC0007

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag CCU04_RS24305 Protein ID WP_000239579.1
Coordinates 4748592..4748942 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag CCU04_RS24310 Protein ID WP_001223208.1
Coordinates 4748936..4749187 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCU04_RS24285 4744038..4745060 - 1023 WP_001298926.1 ABC transporter permease -
CCU04_RS24290 4745074..4746576 - 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
CCU04_RS24295 4746716..4747672 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
CCU04_RS24300 4747982..4748512 + 531 WP_000055072.1 inorganic diphosphatase -
CCU04_RS24305 4748592..4748942 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
CCU04_RS24310 4748936..4749187 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
CCU04_RS24315 4749400..4749741 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
CCU04_RS24320 4749744..4753523 - 3780 WP_000060983.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T110629 WP_000239579.1 NZ_CP031908:c4748942-4748592 [Escherichia coli O103:H2]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T110629 NZ_CP031908:c4748942-4748592 [Escherichia coli O103:H2]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT110629 WP_001223208.1 NZ_CP031908:c4749187-4748936 [Escherichia coli O103:H2]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT110629 NZ_CP031908:c4749187-4748936 [Escherichia coli O103:H2]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References