Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4537906..4538950 Replicon chromosome
Accession NZ_CP031906
Organism Escherichia coli O91:H21 strain FWSEC0008

Toxin (Protein)


Gene name panT Uniprot ID A0A3W2VTW9
Locus tag CAX06_RS22415 Protein ID WP_000089360.1
Coordinates 4537906..4538454 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag CAX06_RS22420 Protein ID WP_000287252.1
Coordinates 4538477..4538950 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAX06_RS22380 4533913..4534275 + 363 WP_000135680.1 hypothetical protein -
CAX06_RS22385 4534341..4535165 + 825 WP_000081316.1 DUF2303 family protein -
CAX06_RS22390 4535293..4535829 + 537 WP_000008232.1 5'-deoxynucleotidase -
CAX06_RS22395 4535820..4536182 + 363 WP_001242725.1 hypothetical protein -
CAX06_RS22400 4536182..4536991 + 810 WP_000206746.1 hypothetical protein -
CAX06_RS22405 4536991..4537563 + 573 WP_001061343.1 3'-5' exoribonuclease -
CAX06_RS22410 4537600..4537872 + 273 WP_001093911.1 pyocin activator PrtN family protein -
CAX06_RS22415 4537906..4538454 - 549 WP_000089360.1 hypothetical protein Toxin
CAX06_RS22420 4538477..4538950 - 474 WP_000287252.1 SocA family protein Antitoxin
CAX06_RS22425 4539238..4539360 - 123 WP_001300034.1 hypothetical protein -
CAX06_RS22430 4539724..4540747 - 1024 Protein_4316 DUF2713 domain-containing protein -
CAX06_RS22440 4541065..4541580 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
CAX06_RS22445 4541622..4541831 - 210 WP_001030593.1 CsbD family protein -
CAX06_RS22450 4541947..4543272 - 1326 WP_001295692.1 MATE family efflux transporter DinF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stx2B / stx2A 4488860..4543953 55093


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20028.54 Da        Isoelectric Point: 4.6708

>T110598 WP_000089360.1 NZ_CP031906:c4538454-4537906 [Escherichia coli O91:H21]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFESSNHESDDGSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Download         Length: 549 bp

>T110598 NZ_CP031906:c4538454-4537906 [Escherichia coli O91:H21]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGTCGTCTAATCATGAGAGCGATGATGGTTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGCTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTGGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT110598 WP_000287252.1 NZ_CP031906:c4538950-4538477 [Escherichia coli O91:H21]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT110598 NZ_CP031906:c4538950-4538477 [Escherichia coli O91:H21]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W2VTW9

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References