Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 952367..953021 Replicon chromosome
Accession NZ_CP031906
Organism Escherichia coli O91:H21 strain FWSEC0008

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag CAX06_RS04690 Protein ID WP_000244777.1
Coordinates 952614..953021 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CAX06_RS04685 Protein ID WP_000354046.1
Coordinates 952367..952633 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAX06_RS04660 947536..948279 + 744 WP_000951964.1 SDR family oxidoreductase -
CAX06_RS04665 948336..949769 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
CAX06_RS04670 949814..950125 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
CAX06_RS04675 950289..950948 + 660 WP_000250274.1 hemolysin III family protein -
CAX06_RS04680 951144..952124 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
CAX06_RS04685 952367..952633 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CAX06_RS04690 952614..953021 + 408 WP_000244777.1 toxin CptA Toxin
CAX06_RS04695 953061..953582 - 522 WP_001055874.1 flavodoxin FldB -
CAX06_RS04700 953694..954590 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CAX06_RS04705 954615..955325 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CAX06_RS04710 955331..957064 + 1734 WP_000813223.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T110582 WP_000244777.1 NZ_CP031906:952614-953021 [Escherichia coli O91:H21]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T110582 NZ_CP031906:952614-953021 [Escherichia coli O91:H21]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT110582 WP_000354046.1 NZ_CP031906:952367-952633 [Escherichia coli O91:H21]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT110582 NZ_CP031906:952367-952633 [Escherichia coli O91:H21]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References