Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 783605..784403 | Replicon | chromosome |
| Accession | NZ_CP031906 | ||
| Organism | Escherichia coli O91:H21 strain FWSEC0008 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | CAX06_RS03830 | Protein ID | WP_000854902.1 |
| Coordinates | 783605..783982 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A093DMQ4 |
| Locus tag | CAX06_RS03835 | Protein ID | WP_001280952.1 |
| Coordinates | 784029..784403 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CAX06_RS03800 | 778951..779928 | + | 978 | WP_000633193.1 | type II secretion system minor pseudopilin GspK | - |
| CAX06_RS03805 | 779925..781103 | + | 1179 | WP_000094987.1 | type II secretion system protein GspL | - |
| CAX06_RS03810 | 781105..781641 | + | 537 | WP_000942798.1 | GspM family type II secretion system protein YghD | - |
| CAX06_RS03815 | 781984..782826 | - | 843 | WP_001280537.1 | DUF4942 domain-containing protein | - |
| CAX06_RS03820 | 782911..783108 | - | 198 | WP_000839261.1 | DUF957 domain-containing protein | - |
| CAX06_RS03825 | 783120..783608 | - | 489 | WP_000779175.1 | hypothetical protein | - |
| CAX06_RS03830 | 783605..783982 | - | 378 | WP_000854902.1 | TA system toxin CbtA family protein | Toxin |
| CAX06_RS03835 | 784029..784403 | - | 375 | WP_001280952.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CAX06_RS03840 | 784566..784787 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| CAX06_RS03845 | 784850..785326 | - | 477 | WP_001186725.1 | RadC family protein | - |
| CAX06_RS03850 | 785342..785827 | - | 486 | WP_000849590.1 | antirestriction protein | - |
| CAX06_RS03855 | 785882..786700 | - | 819 | WP_001234626.1 | DUF945 domain-containing protein | - |
| CAX06_RS03865 | 786800..787033 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| CAX06_RS03870 | 787112..787567 | - | 456 | WP_000581507.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM | 670325..856904 | 186579 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14307.29 Da Isoelectric Point: 7.2922
>T110581 WP_000854902.1 NZ_CP031906:c783982-783605 [Escherichia coli O91:H21]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T110581 NZ_CP031906:c783982-783605 [Escherichia coli O91:H21]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13719.50 Da Isoelectric Point: 6.6249
>AT110581 WP_001280952.1 NZ_CP031906:c784403-784029 [Escherichia coli O91:H21]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
Download Length: 375 bp
>AT110581 NZ_CP031906:c784403-784029 [Escherichia coli O91:H21]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|