Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3146001..3146819 | Replicon | chromosome |
| Accession | NZ_CP031902 | ||
| Organism | Escherichia coli O104:H4 strain FWSEC0009 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0E0Y102 |
| Locus tag | C8200_RS15975 | Protein ID | WP_000771609.1 |
| Coordinates | 3146001..3146375 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0E0Y470 |
| Locus tag | C8200_RS15980 | Protein ID | WP_001285568.1 |
| Coordinates | 3146466..3146819 (-) | Length | 118 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C8200_RS15935 | 3141005..3141496 | - | 492 | WP_001297187.1 | DUF1097 domain-containing protein | - |
| C8200_RS15940 | 3141598..3142152 | - | 555 | WP_001001902.1 | molecular chaperone YcdY | - |
| C8200_RS15945 | 3142176..3142913 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| C8200_RS15950 | 3142968..3143906 | - | 939 | WP_000351313.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| C8200_RS15960 | 3144377..3145219 | - | 843 | WP_001274560.1 | DUF4942 domain-containing protein | - |
| C8200_RS15965 | 3145304..3145501 | - | 198 | WP_000839270.1 | DUF957 domain-containing protein | - |
| C8200_RS15970 | 3145513..3146004 | - | 492 | WP_000976860.1 | hypothetical protein | - |
| C8200_RS15975 | 3146001..3146375 | - | 375 | WP_000771609.1 | TA system toxin CbtA family protein | Toxin |
| C8200_RS15980 | 3146466..3146819 | - | 354 | WP_001285568.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| C8200_RS15985 | 3146895..3147116 | - | 222 | WP_000692357.1 | DUF987 domain-containing protein | - |
| C8200_RS15990 | 3147179..3147655 | - | 477 | WP_001186756.1 | RadC family protein | - |
| C8200_RS15995 | 3147671..3148144 | - | 474 | WP_000855049.1 | antirestriction protein | - |
| C8200_RS16000 | 3148238..3148483 | - | 246 | WP_001164966.1 | hypothetical protein | - |
| C8200_RS16005 | 3148483..3149304 | - | 822 | WP_001241709.1 | DUF945 domain-containing protein | - |
| C8200_RS16015 | 3149525..3149935 | - | 411 | WP_000846716.1 | hypothetical protein | - |
| C8200_RS16020 | 3149951..3150634 | - | 684 | WP_000775510.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14006.09 Da Isoelectric Point: 7.2652
>T110567 WP_000771609.1 NZ_CP031902:c3146375-3146001 [Escherichia coli O104:H4]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T110567 NZ_CP031902:c3146375-3146001 [Escherichia coli O104:H4]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 118 a.a. Molecular weight: 13064.82 Da Isoelectric Point: 5.9541
>AT110567 WP_001285568.1 NZ_CP031902:c3146819-3146466 [Escherichia coli O104:H4]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
Download Length: 354 bp
>AT110567 NZ_CP031902:c3146819-3146466 [Escherichia coli O104:H4]
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y102 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y470 |